potential COVID-19 treatments living meta-analysis of clinical studies

demonstrated suggested inconclusive safety concern ongoing study display ongoing demontrated benefit only

60 studies excluded by filtering options 1

5092	Yang, 2020	1	13	3		not a RCT	high risk of bias
5228	Bean, 2020	1	19	3		not a RCT	high risk of bias
5295	Zhang, 2020	1	13	3		not a RCT	high risk of bias
5331	Li, 2020	1	13	4		not a RCT	high risk of bias
5332	Meng, 2020	1	13	4		not a RCT	high risk of bias
5345	Yan et al., 2020	1	20	4		not a RCT	high risk of bias
5346	Mancia, 2020	1	20	3		not a RCT	high risk of bias
5347	Mehra, 2020	2	12	4	excluded	not a RCT	high risk of bias
5348	Reynolds (COVID positive patient), 2020	1	13	3		not a RCT	high risk of bias
5349	Reynolds (prophylaxis), 2020	1	13	3		not a RCT	high risk of bias
5370	Khera (outpatients), 2020	1	13	3		not a RCT	high risk of bias
5372	Khera (inpatients), 2020	1	13	3		not a RCT	high risk of bias
5399	Northwell Consortium (Richardson), 2020	0	99	0	selection pending
5440	Morales, 2020	1	13	0		not a RCT	risk of bias not avaialble
5604	Schneeweiss, 0	0	13	0	selection pending
5605	Vila-Corcole, 0	0	13	0	selection pending
5619	Pan, 2020	0	13	0	selection pending
5797	Rossi, 0	0	13	0	selection pending
5903	Anzola, 2020	0	10	0	selection pending
6660	Bae, 2021	0	12	0	selection pending
6729	Shah, 2021	1	13	3		not a RCT	high risk of bias
6788	Waissengrin, 2021	0	13	0	selection pending
6790	Pawlowski, 2021	1	13	0		not a RCT	risk of bias not avaialble
6894	Andrejko, 2021	1	20	0		not a RCT	risk of bias not avaialble
6927	Rossman, 2021	0	13	0	selection pending
6931	Yair, 2921	1	32	0		not a RCT	risk of bias not avaialble
6934	Boyarsky, 2021	1	32	0		not a RCT	risk of bias not avaialble
6949	Pawlowski, 2021	1	13	0		not a RCT	risk of bias not avaialble
6981	Public Health England (Harris), 2021	1	13	3		not a RCT	high risk of bias
7025	Haberman, 2021	0	13	0	selection pending
7070	PHE variants (Technical briefing 12 22 may 2021), 2021	2	20	2	excluded	not a RCT
7325	Skowronski, 2021	0	13	0	selection pending
7419	Scotland delta (Sheikh), 2021	1	20	3		not a RCT	high risk of bias
7420	PHE (Stowe), 2021	2	13	3	excluded	not a RCT	high risk of bias
7950	Harris, 2021	1	13	3		not a RCT	high risk of bias
8143	Butt, 2021	1	20	2		not a RCT
8147	Canada (Nasreen), 2021	1	20	2		not a RCT
8149	PHE Technical briefing 16 (11/18 June 2021), 2021	2	13	3	excluded	not a RCT	high risk of bias
8150	Ramasamy, 2021	0	32	0	selection pending
8164	Public Health England, May 16, 2021 (Bernal), 2021	1	20	2		not a RCT
8255	REACT-SCOT, 2021	1	20	0		not a RCT	risk of bias not avaialble
8272	Martinez-Baz, 2021	1	13	0		not a RCT	risk of bias not avaialble
8274	REACT-1 round 13 final report (Elliott, Imperial College London), 2021	1	13	3		not a RCT	high risk of bias
8275	Musser, 2021	2	13	0	excluded	not a RCT	risk of bias not avaialble
8294	CDC Mesa County, Colorado, 2021	1	13	3		not a RCT	high risk of bias
8313	Bahl (Fully vaccinated vs unvaccinated), 2021	0	10	0	selection pending
8350	Rosenberg, 2021	2	13	0	excluded	not a RCT	risk of bias not avaialble
8359	Oxford (Pouwels), 2021	1	13	2		not a RCT
8360	HEROES-RECOVER (Fowlkes), 2021	1	13	3		not a RCT	high risk of bias
8513	Grannis, 2021	1	20	3		not a RCT	high risk of bias
8514	VA (Bajema), 2021	1	20	3		not a RCT	high risk of bias
8515	Scobie, 2021	2	20	0	excluded	not a RCT	risk of bias not avaialble
9170	UKHSA report 33 (23 december 2021), 2021	2	20	0	excluded	not a RCT	risk of bias not avaialble
9176	UKHSA 31 december 2021, 2021	2	20	0	excluded	not a RCT	risk of bias not avaialble
9214	Southern California (Lewnard), 2022	2	13	0	excluded	not a RCT	risk of bias not avaialble
9216	Sultan, 2022	0	12	0	selection pending
9267	Ostropolets, 2021	0	12	0	selection pending
9294	UKHSA (report W4- 27 January), 2022	2	12	0	excluded	not a RCT	risk of bias not avaialble
9491	Li X, 2022	1	12	0		not a RCT	risk of bias not avaialble
9590	UKHSA report week 12 (24 March 2022), 2022	1	12	0		not a RCT	risk of bias not avaialble

	infections other than COVID-19
potential COVID-19 treatments
adjuvant therapies
face mask	MacIntyre ... MacIntyre ...
anti-inflammatoty and immuno-therapy
Immunostimulants drugs
convalescent plasma treatment	Hung IRC002 Study Team IRC005 Study Team INSIGHT FLU-IVIG ...
antiviral and associated therapy
chloroquine and derivatives	CuraChik ... Peymani Borges Paton Tricou
vaccines
ebola vaccine	Ishola ... EBOVAC2
Non replicating viral vector
Ad26.RSV.preF (respiratory syncytial virus)	Sadoff
Ad26.ZEBOV ()	Afolabi
Ad26.ZIKV.001 (Ad26-Vectored Anti-Zika Virus Vaccine)	Salisch