chloroquine and derivatives living meta-analysis of clinical studies

demonstrated suggested inconclusive safety concern ongoing study display ongoing demontrated benefit only

	COVID 19 hospitalized
	COVID 19 hospitalized	COVID 19 all comers	COVID-19 mild to moderate	COVID-19 severe or critically
chloroquine and derivatives
chloroquine	Huang
hydroxychloroquine	RECOVERY HYCOVID Gonzalez ... SOLIDARITY ... Abd-Elsalam HAHPS ORCHID TEACH Chen NO COVID-19 ...	NOR-Solidarity ...	Coalition Covid-19 Brazil I ... FACCT Trial	HYDRA ...

85 studies excluded by filtering options 0

4824	HC-nCoV (Shanghai), 2020	1	1	3			high risk of bias
4841	Tang, 2020	1	1	3			high risk of bias
4864	Zhaowei Chen, 2020	1	1	3			high risk of bias
4887	Gautret et al., 2020	1	31	3		not a RCT	high risk of bias
4893	ChiCTR2000030054-HCQ (Chen), 2020	1	1	3			high risk of bias
4899	ChiCTR2000029826 (Cancelled by the investigator), 0	2	1	0	excluded		risk of bias not avaialble
4905	ChiCTR2000029975, 0	2	30	0	excluded	not a RCT	risk of bias not avaialble
4987	CloroCOVID19, 2020	2	1	3	excluded		high risk of bias
5056	Lopez, 2020	0	13	0	selection pending
5226	Duke university (Hydroxychloroquine), 2020	2	1	0	excluded		risk of bias not avaialble
5258	Duke University hydroxychloroquine/azithromycine, 2020	1	1	0			risk of bias not avaialble
5267	Mahevas, 2020	1	13	3		not a RCT	high risk of bias
5287	Chen_chloroquine, 2020	1	13	4		not a RCT	high risk of bias
5288	Barbosa, 2020	2	13	0	excluded	not a RCT	risk of bias not avaialble
5300	Raquel, 2019	2	1	0	excluded		risk of bias not avaialble
5302	Peymani, 2016	1	1	3			high risk of bias
5303	Jacobson, 2016	2	1	0	excluded		risk of bias not avaialble
5307	CuraChik (De Lamballerie), 2008	1	1	3			high risk of bias
5308	Sperber, 1995	2	1	0	excluded		risk of bias not avaialble
5309	Paton, 2012	2	1	0	excluded		risk of bias not avaialble
5313	Magagnoli (HC), 2020	1	13	3		not a RCT	high risk of bias
5350	Yu, 2020	1	13	4		not a RCT	high risk of bias
5351	Mallat, 2020	2	13	0	excluded	not a RCT	risk of bias not avaialble
5354	Geleris, 2020	1	13	3		not a RCT	high risk of bias
5365	Rosenberg, 2020	1	13	3		not a RCT	high risk of bias
5367	Huang, 2020	1	13	4		not a RCT	high risk of bias
5368	Novales, 2020	1	13	4		not a RCT	high risk of bias
5374	Million, 2020	2	30	0	excluded	not a RCT	risk of bias not avaialble
5375	Mehra, 2020	2	13	3	excluded	not a RCT	high risk of bias
5416	Guerin, 2020	2	31	4	excluded	not a RCT	high risk of bias
5445	Nguyen, 2020	0	21	0	selection pending
5448	COVID-19 Global Rheumatology Alliance, 2020	0	13	0	selection pending
5451	Raja, 2020	0	13	0	selection pending
5470	Singh, 2020	0	21	0	selection pending
5475	Bhattacharya, 2020	0	13	0	selection pending
5478	Paccoud, 2020	1	13	3		not a RCT	high risk of bias
5481	Sbidian (HCQ alone), 2020	1	13	4		not a RCT	high risk of bias
5512	Arshad (HCQ), 2020	1	13	4		not a RCT	high risk of bias
5517	Min, 2020	1	13	0		not a RCT	risk of bias not avaialble
5518	EPI-PHARE, 0	1	13	3		not a RCT	high risk of bias
5564	Kanran M, 2020	2	1	0	excluded		risk of bias not avaialble
5566	Lofgren SMM, 2020	0	13	0	selection pending
5596	Kalligeros, 2020	0	13	0	selection pending
5599	Karolyi, 2020	0	13	0	selection pending
5681	Lane, 2020	0	13	0	selection pending
5762	Belgian Collaborative Group on COVID-19, 2020	1	13	3		not a RCT	high risk of bias
5776	Alberici, 2020	2	13	4	excluded	not a RCT	high risk of bias
5778	Cravedi, 2020	0	13	0	selection pending
5780	Fontana, 2020	0	13	0	selection pending
5789	Singh, 2020	1	13	4		not a RCT	high risk of bias
5842	Rentsch, 2020	1	13	0		not a RCT	risk of bias not avaialble
5860	CCAP-1, 2020	1	1	0			risk of bias not avaialble
5861	Duke university HCQ, 2020	1	1	0			risk of bias not avaialble
5862	ARCHAIC -hydroxychloroquine, 2020	1	1	0			risk of bias not avaialble
5863	NCT04342650, 2020	1	1	0			risk of bias not avaialble
5864	HYDRA, 2020	2	1	0	excluded		risk of bias not avaialble
5866	NCT04333654, 2020	1	1	0			risk of bias not avaialble
5868	PROTECT B, 2020	1	1	0			risk of bias not avaialble
5874	COMIHY, 2020	1	1	0			risk of bias not avaialble
5875	OAHU-COVID19, 2020	1	1	0			risk of bias not avaialble
5878	REMAP-CAP-HCQ, 2020	1	1	0			risk of bias not avaialble
5881	Grau-Pujol, 2020	1	1	3			high risk of bias
5930	Abella, 2020	1	0	0			risk of bias not avaialble
5974	ARCHAIC - Chloroquine, 2020	0	1	0	selection pending
5976	Chen, ChiCTR2000030054 - Chloroquine, 2020	1	1	3			high risk of bias
6010	Gendelman, 2020	1	13	0		not a RCT	risk of bias not avaialble
6032	Mohana, 2020	2	12	0	excluded	not a RCT	risk of bias not avaialble
6035	NCT04597775, 0	0	0	0	selection pending
6047	Hsia, 2020	0	99	0	selection pending
6047	Hsia, 2020	0	99	0	selection pending
6246	IRCT20150808023559N20, 0	0	1	0	selection pending
6252	NCT04376814-Group A, 2020	0	31	0	selection pending
6255	IRCT20200428047228N1 // U07, 0	0	1	0	selection pending
6279	Q-PROTECT -HCQ alone, 2020	1	1	0			risk of bias not avaialble
6358	Jung, 2020	0	12	0	selection pending
6466	Agusti, 2020	1	10	0		not a RCT	risk of bias not avaialble
6697	Thakar, 2021	2	1	0	excluded		risk of bias not avaialble
6799	Dubee, 2021	0	0	0	selection pending
6910	Thakar, 2021	2	1	0	excluded		risk of bias not avaialble
6926	PROTECT A, 2020	1	1	0			risk of bias not avaialble
7018	Kamran, 2020	1	1	3			high risk of bias
9243	Sarhan, 2022	0	1	0	selection pending
9328	Syed, 2021	1	1	3			high risk of bias
9374	Rojas-Serrano, 2022	0	0	0	selection pending
10256	Seet (HCQ), 2021	1	1	3			high risk of bias