Non replicating viral vector for COVID-19: living meta-analysis of clinical studies

potential COVID-19 treatments
adjuvant therapies
anticoagulant
anticoagulant, curative dose
anticoagulant, pre-admission
anticoagulant, prophylactic dose
anticoagulation, intermediate prophylactic dose
Bivalirudin
enoxaparin
heparin at therapeutic dose
P2Y12 inhibitors
rivaroxaban
sulodexide
face mask
febuxostat
hydrogen-oxygen nebulizer
hyperbaric oxygen
nintedanib
paracetamol
pulmonary rehabilitation
respiratory support
anti-inflammatoty and immuno-therapy
anti-inflammatory therapies
anti GM-CSF
mavrilimumab
Namilumab
otilimab
clarithromycine
colchicine
Colchicine plus rosuvastatin
mepolizumab
naproxen, ibuprofen
non-steroidal anti-inflammatory drugs
Celecoxib
Ibuprofen
Indomethacin
selinexor
sodium aescinate
stem cells
tradipitant
vilobelimab (IFX-1)
Apilimod
corticosteroids
ciclesonide
dexamethasone
Dexamethasone 12mg
dexamethasone 6mg
Hydrocortisone
low-dose corticosteroids
methylprednisolone
Immunostimulants drugs
anti-PD-1 antibody
CD24Fc
convalescent plasma treatment
Deferred Convalescent plasma
Early convalescent plasma.
immunoglobulin therapy
inactivated mycobacterium vaccine
interferon
IFN beta-1a
high-dose IFN beta-1a
IFN beta-1b
IFN gamma
inhaled interferon
IFN alpha
pegylated interferon-α2b
recombinant super-compound interferon rSIFN-co
SNG001 inhaled interferon beta
interferon / TFF2
peginterferon
PNB001
Interleukin-2
levamisole
neutralizing antibody
amubarvimab/romlusevimab (BRII-196 and BRII-198-Brii Biosciences)
bamlanivimab monotherapy
bamlanivimab/etesevimab
Bebtelovimab (LY-CoV1404)
bevacizumab
casirivimab/imdevimab (Ronapreve)
cilgavimab and tixagevimab (Evusheld)
equine polyclonal antibodies INM005
regdanvimab (Regkirona- CT-P59-Celltrion)
sotrovimab (Xevudy; VIR-7831)
XAV-19
rhG-CSF
Immunosuppressants drugs
abatacept
adalimumab
anakinra
anti-interleukin-6
clazakizumab
Levilimab
sarilumab
sarilumab azithromycin hydroxychloroquine
sarilumab high dose (400mg)
sarilumab low dose (200mg)
siltuximab
tocilizumab
canakinumab
cenicriviroc
complement inhibitors
conestat alfa
ravulizumab
CRAC-channel inhibitors (auxora)
eculizumab
emapalumab
fostamatinib
infliximab
itolizumab
ixekizumab
jakotinib
janus kinase (JAK) inhibitor
baricitinib
baricitinib plus remdesivir
ruxolitinib
TD-0903
TD-0903 10mg
TD-0903 1mg
TD-0903 3mg
tofacitinib
lenzilumab
pamrevlumab
tacrolimus
tetrandrine
thalidomide
inhaled corticosteroids
budesonide
Kinase inhibitors
acalabrutinib
imatinib
leflunomide
meplazumab
pirfenidone
Polyinosinic-Polycytidylic Acid
sargramostim
statins
Atorvastatin
thymosin
antiandrogenic
5-alpha-reductase inhibitors
dutasteride
progesterone
proxalutamide
antiviral and associated therapy
Amantadine
ASC09/ritonavir
azithromycin
azvudine
baloxavir marboxil
bromhexine
carrimycin
chloroquine and derivatives
chloroquine
hydroxychloroquine
zinc plus hydroxychloroquine
danoprevir / ritonavir
darunavir cobicistat
darunavir/cobicistat plus chloroquine
doxycycline
Emtricitabine/tenofovir plus colchicine plus rosuvastatin
Ensitrelvir (XOCOVA)
favipiravir
favipiravir plus interferon
fluvoxamine
hydroxychloroquine plus macrolides
azithromycin plus hydroxychloroquine
Interferon plus lopinavir/ritonavir
ivermectin
ivermectin plus doxycycline
leronlimab
lopinavir / ritonavir plus ribavirin
lopinavir/ritonavir
lopinavir/ritonavir plus chloroquine
Lopinavir/ritonavir plus hydroxychloroquine
lopinavir/ritonavir plus interferon ß-1a
lopinavir/ritonavir, ribavirin and interferon beta-1b
molnupiravir
niclosamide
nirmatrelvir / ritonavir (Paxlovid)
nitazoxanide
opaganib
oseltamivir
oseltamivir plus chloroquin
remdesivir
ribavirin
ritonavir
sofosbuvir
sofosbuvir and daclatasvir
sofosbuvir and ledipasvir
tenofovir/emtricitabine
tenofovir/emtricitabine plus hydroxychloroquine
tranexamic acid
tranilast
triazavirin
umifenovir (arbidol)
zinc
control
placebo
prone positioning
standard of care
uncontrolled study
Drugs for acid related disorders
bismuth
H2 blockers
famotidine
proton pump inhibitors (PPI)
miscellaneous
2-deoxy-D-glucose (2-DG)
acetylcysteine
alpha lipoic acid
anti-CK2
Aspirin
aviptadil
BLD-2660 (calpain inhibitor)
calcium channel blocker
camostat mesilate
Cannabidiol
continuous positive airway pressure (CPAP)
cytokine adsorption
diammonium glycyrrhizinate
dipyridamol
dornase alfa
expectorants and mucolytics
honey
kinin-kallikrein inhibitors
melatonin
mouthrise and gargling agents
mouthrinses
N-Acetylcysteine
nasal spray
nasal spray containing Iota-Carrageenan
natural killer (NK) cells
nicotin
nigella sativa oil
nitric oxide (gas Inhalation or releasing solution)
omega-3 Polyunsaturated Fatty Acids
ozonated autohemotherapy
plasma exchange
povidone-iodine
previfenon (EGCG)
prostacyclin
PUL-042 inhalation solution
pyridostigmine
radiotherapy
sabizabulin
sildenafil
triiodothyronine (T3)
Oral antidiabetic drugs
dapagliflozin
DPP-4 inhibitor
metformin
Renin-angiotensin-system-acting agents
angiotensin converting enzyme inhibitors (ACEIs)
angiotensin receptor blockers (ARBs)
losartan
angiotensin-(1-7)
continuation of ACEI/ARB
discontinuation of ACEI/ARB
RAS blocker withdrawal
rhACE2
vaccines
A EFFACER BBV152 (Bharat Biotech, India)
A EFFACER Janssen Ad.26.COV2.S vaccine (JNJ-78436725)
A EFFACER_ Vero cell
A EFFACER_sequential Immunization
BCG vaccination
complete primary vaccine series
CoVLP (MT-2766, Medicago)
DNA vaccine
bacTRL-Spike
Zy-Cov-D (Zydus Cadila)
ebola vaccine
first booster dose
mRNA vaccine (any) - first boost
Comirnaty - first boost
Spikevax - first boost
Non replicating viral vector -first boost
Janssen AD26 vaccine - fisrt boost
Vaxzevria -first boost
heterologous prime-boost
Inactivated virus vaccine
CoronaVac (SinoVac)
Covaxin, Bharat Biotech (BBV152)
Shifa-Pharmed inactivated vaccine
Sinopharm Beijing (BBIBP-CorV)
Sinopharm Wuhan
mRNA vaccine
Comirnaty (tozinameran - Pfizer/BIONTECH)
CureVac
Spikevax (Moderna mRNA-1273 COVID-19 vaccine)
Non replicating viral vector
Ad26.RSV.preF (respiratory syncytial virus)
Ad26.ZEBOV ()
Ad26.ZIKV.001 (Ad26-Vectored Anti-Zika Virus Vaccine)
CanSino (Convidecia)
Covishield (Oxford/AZ formulation)
Janssen AD26 vaccine (JNJ-78436735)
Sputnik V (Gam-COVID-Vac)
SPUTNIK-LIGHT
Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19)
protein subunit vaccine
Anhui Zhifei Longcom
CoVax-19 SpikoGen
Nuvaxovid (NVX-CoV2373) Novavax
Sanofi/GSK recombinant protein vaccine
SCB-2019
Replicating Viral Vector
seasonal influenza vaccines
second booster dose
mRNA vaccine (any) - second boost
Comirnaty - second boost
Spikevax - second boost
virus-like particles vaccine
Medicago
Vitamins
vitamin C
zinc plus vitamin c
Vitamin D
hight dose vitamin D
RACINE

vs. potential COVID-19 treatments
vs. control
vs. placebo
vs. vaccines
vs. Inactivated virus vaccine
vs. CoronaVac (SinoVac)
vs. mRNA vaccine
vs. Comirnaty (tozinameran - Pfizer/BIONTECH)

All
COVID 19 hospitalized
COVID 19 all comers
COVID-19 mild to moderate
COVID-19 severe or critically
COVID 19 outpatients
COVID-19 (hospitalized or not)
COVID-19 prophylaxis (children)
COVID-19 prophylaxis (excluding children)
infections other than COVID-19
Long COVID-19
preventing respiratory virus transmission
root
secondary prevention

Studies
Mapping
Meta-analysis
Excluded 6

table network network 2

display ongoing demontrated benefit only

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Li J, 2022 NCT04892459

CanSino (Convidecia) vs. CoronaVac (SinoVac)

COVID-19 prophylaxis (excluding children)

CanSino phase 3, 2021 NCT04526990

CanSino (Convidecia) vs. placebo

COVID-19 prophylaxis (excluding children)

CanSino phase 2 (Zhu), 2020 NCT04341389

CanSino (Convidecia) vs. placebo

COVID-19 prophylaxis (excluding children)

Fengcai, 2021 NCT04566770

CanSino (Convidecia) vs. placebo

COVID-19 prophylaxis (excluding children)

NCT04540419, 0 NCT04540419

CanSino (Convidecia) vs. placebo

COVID-19 prophylaxis (excluding children)

Kulkarni, 2021 CTRI/2020/08/027170

Covishield (Oxford/AZ formulation) vs. placebo

COVID-19 prophylaxis (excluding children)

Reindl-Schwaighofer, 2021

Janssen AD26 vaccine (JNJ-78436735) vs. Comirnaty (tozinameran - Pfizer/BIONTECH)

COVID-19 prophylaxis (excluding children)

Botton (EPI-PHARE), 2022

Janssen AD26 vaccine (JNJ-78436735) vs. Comirnaty (tozinameran - Pfizer/BIONTECH)

COVID-19 prophylaxis (excluding children)

EPIPHARE (Janssen), 2022

Janssen AD26 vaccine (JNJ-78436735) vs. control

COVID-19 prophylaxis (excluding children)

Sisonke study (bekker), 2022 NCT04838795

Janssen AD26 vaccine (JNJ-78436735) vs. control

COVID-19 prophylaxis (excluding children)

Husby (janssen), 2021

Janssen AD26 vaccine (JNJ-78436735) vs. control

COVID-19 prophylaxis (excluding children)

Pawlowski, 2021

Janssen AD26 vaccine (JNJ-78436735) vs. control

COVID-19 prophylaxis (excluding children)

Sisonke 2 (booster), 2021 NCT05148845

Janssen AD26 vaccine (JNJ-78436735) vs. control

COVID-19 prophylaxis (excluding children)

HORIZON 1, 0 NCT04765384

Janssen AD26 vaccine (JNJ-78436735) vs. Janssen AD26 vaccine (JNJ-78436735)

COVID-19 prophylaxis (excluding children)

MixNMatch Study, 2021 NCT04889209

Janssen AD26 vaccine (JNJ-78436735) vs. mRNA vaccine

COVID-19 prophylaxis (excluding children)

Sadoff, 2021 NCT04436276

Janssen AD26 vaccine (JNJ-78436735) vs. placebo

COVID-19 prophylaxis (excluding children)

ENSEMBLE (COV3001), 0 NCT04505722

Janssen AD26 vaccine (JNJ-78436735) vs. placebo

COVID-19 prophylaxis (excluding children)

ENSEMBLE 2 (3009), 0 NCT04614948

Janssen AD26 vaccine (JNJ-78436735) vs. placebo

COVID-19 prophylaxis (excluding children)

Pitisuttithum, 2022 NCT04764422

Non replicating viral vector vs. placebo

COVID-19 prophylaxis (excluding children)

Rearte, 2022

Sputnik V (Gam-COVID-Vac) vs. control

COVID-19 prophylaxis (excluding children)

Nabirova, 2022

Sputnik V (Gam-COVID-Vac) vs. control

COVID-19 prophylaxis (excluding children)

RESIST (Sputnik V Gamaleya Research Institute Russia), 2020 NCT04530396

Sputnik V (Gam-COVID-Vac) vs. placebo

COVID-19 prophylaxis (excluding children)

04-Gam-COVID-Vac-2020-RB, 0 NCT04564716

Sputnik V (Gam-COVID-Vac) vs. placebo

COVID-19 prophylaxis (excluding children)

NCT04954092, 0 NCT04954092

Sputnik V (Gam-COVID-Vac) vs. placebo

COVID-19 prophylaxis (excluding children)

NCT04656613, 0 NCT04656613

Sputnik V (Gam-COVID-Vac) vs. placebo

COVID-19 prophylaxis (excluding children)

NCT04640233, 0 NCT04640233

Sputnik V (Gam-COVID-Vac) vs. placebo

COVID-19 prophylaxis (excluding children)

Com-COV, 2021 ISRCTN69254139

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. Comirnaty (tozinameran - Pfizer/BIONTECH)

COVID-19 prophylaxis (excluding children)

Nguyen, 2021

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. Comirnaty (tozinameran - Pfizer/BIONTECH)

COVID-19 prophylaxis (excluding children)

Kanokudom, 2022

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. complete primary vaccine series

COVID-19 prophylaxis (excluding children)

Bernal, 0

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

AstraZeneca Oxford pooled analysis (COV003, COV001, COV002, COV005)_safety, 2020

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

Patone, 2021

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

Husby (Astra), 2021

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

Scotland cohort, 0

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

Edward (Vaxzevria), 2021

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

EPIPHARE (Vaxzevria), 2022

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

Rearte, 2022

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

Burn (Vaxzevria), 2021

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

Folegatti, 2020

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

Hippisley-Cox, 2021

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

Bernal (PHE, 19th February 2021), 2021

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

Simpson (ChAdOx1), 2021

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

ChAdOx1 phase 3 (AstraZeneca), 2020 NCT04400838

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

Pottegard, 2021

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

Sultan, 2022

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

Clemens, 2021 ISRCTN89951424

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. control

COVID-19 prophylaxis (excluding children)

Bonelli, 2022

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. mRNA vaccine

COVID-19 prophylaxis (excluding children)

AstraZeneca phase 3 US (D8110C00001), 2021 NCT04516746

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. placebo

COVID-19 prophylaxis (excluding children)

COV005, 2021 NCT04444674

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. placebo

COVID-19 prophylaxis (excluding children)

Asano, 2022 NCT04568031

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. placebo

COVID-19 prophylaxis (excluding children)

AstraZeneca phase 3 US (D8110C00001) 6 month follow up, 2021 NCT04516746

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. placebo

COVID-19 prophylaxis (excluding children)

Candidate COVID-19 Vaccine (COV001), 2020 NCT04324606

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. placebo

COVID-19 prophylaxis (excluding children)

John, 2021 NCT04400838

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. uncontrolled study

COVID-19 prophylaxis (excluding children)

Com-COV2, 2022 ISRCTN 27841311

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. vaccines

COVID-19 prophylaxis (excluding children)

ComFluCOV (ChadOx1 plus influenza vaccines), 2021 ISRCTN14391248

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19)

COVID-19 prophylaxis (excluding children)

Nanthapisal, 2022

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19)

COVID-19 prophylaxis (excluding children)

Valim, 2022

Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) vs. Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19)

COVID-19 prophylaxis (excluding children)