Azathioprine

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROB
All congenital malformations (majors, minors, majors and minors, or unspecified)1.64 [1.21, 2.23]0%6 studies55,691690serious ROB
Major congenital malformations1.55 [1.05, 2.28]0%4 studies38,274777not evaluable ROB
Congenital heart defects2.02 [1.03, 3.95]-1 study12,591476not evaluable ROB
Cardiac septal defects3.18 [1.56, 6.49]-1 study6,638476not evaluable ROB
1 non statistically significant endpoints reported in only one study

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROB
Preterm (< 37 weeks)3.88 [3.20, 4.71]0%7 studies58,217751not evaluable ROB
Low birth weight (< 2500g)2.51 [1.52, 4.13]42%7 studies37,270724not evaluable ROB
Small for gestational age (weight)2.34 [1.57, 3.49]-1 study24,827466not evaluable ROB
Large for gestational age (weight)0.55 [0.32, 0.95]-1 study68,827466not evaluable ROB
2 non statistically significant endpoints reported in only one study

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROB
1 non statistically significant endpoints reported in only one study

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROB
2 non statistically significant endpoints reported in only one study

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROB
Late intrauterine deaths (> 22 weeks)3.42 [1.18, 9.92]0%3 studies28352not evaluable ROB
Therapeutic terminations of pregnancy1.47 [0.74, 2.90]0%3 studies35340not evaluable ROB
Early intrauterine death (< 22 weeks)0.78 [0.32, 1.90]18%2 studies38140not evaluable ROB
3 non statistically significant endpoints reported in only one study

Neuro-developmental disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROB
1 non statistically significant endpoints reported in only one study