Antithyroid drugs

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome VerdictOR 95%CII2k No. casesNo. exposedpublication biasROB???
All congenital malformations (majors, minors, majors and minors, or unspecified)1.24 [1.10, 1.40]21%12 studies250,10819,467low NA
Major congenital malformations1.32 [0.95, 1.83]0%6 studies1973,475serious NA
Urinary malformations1.69 [1.10, 2.61]58%3 studies17,72915,800not evaluable NA
Genital anomalies1.17 [0.96, 1.41]0%3 studies25,84815,800not evaluable NA
Respiratory system anomalies1.16 [0.67, 2.01]71%3 studies16,03715,800not evaluable NA
Congenital heart defects1.33 [0.98, 1.79]71%3 studies77,71315,800not evaluable NA
Ear, face and neck anomalies1.50 [0.59, 3.82]0%2 studies9172,909not evaluable NA
Eye defects1.39 [0.70, 2.74]0%2 studies2,4932,909not evaluable NA
Limb defects1.08 [0.82, 1.41]61%3 studies74,80015,800not evaluable NA
Severe congenital heart defect0.63 [0.04, 9.47]71%2 studies7392,757not evaluable NA
Abdominal wall defects3.37 [1.63, 6.96]0%2 studies9332,909not evaluable NA
Cardiac septal defects1.87 [1.14, 3.06]-1 study1,097not evaluable NA
Craniosynostosis1.53 [0.43, 5.51]0%3 studies1,5372,684not evaluable NA
Digestive system anomalies1.36 [1.08, 1.71]0%2 studies12,07013,337not evaluable NA
Nervous system anomalies1.45 [1.06, 2.00]0%2 studies5,88413,337not evaluable NA
Syndromes and chromosomal abnormalities0.88 [0.34, 2.27]26%2 studies5,5572,909not evaluable NA
Ano-rectal atresia and stenosis2.04 [0.36, 11.46]53%2 studies1,0562,644not evaluable NA
Aortic valve atresia/stenosis1.75 [0.07, 44.39]71%2 studies4942,643not evaluable NA
Carbimazole embryopathy5.24 [0.80, 34.53]50%2 studies2,04813,095not evaluable NA
Choanal atresia12.25 [5.02, 29.88]0%2 studies119139not evaluable NA
Ear malformations17.48 [0.84, 364.79]-1 study2446not evaluable NA
Omphalocele6.20 [2.78, 13.83]0%2 studies1602,757not evaluable NA
Other congenital malformations (Q80-84)0.18 [0.01, 3.14]-1 study9446not evaluable NA
Situs inversus16.80 [2.99, 94.32]35%2 studies272,757not evaluable NA
Aplasia cutis congenita10.90 [0.62, 190.95]-1 study72,630not evaluable NA
Atresia of bile ducts0.72 [0.05, 11.59]-1 study22,630not evaluable NA
Atresia or stenosis of other parts of small intestine2.17 [0.09, 53.42]-1 study12,630not evaluable NA
Atrial septal defect1.45 [0.13, 16.00]-1 study32,630not evaluable NA
Brachydactyly2.17 [0.09, 53.42]-1 study12,630not evaluable NA
Chromosomal abnormalities1.16 [0.16, 8.29]-1 study4176not evaluable NA
Cleft lip with or without cleft palate0.36 [0.03, 4.00]-1 study32,630not evaluable NA
Club foot / Talipes equinovarus0.24 [0.01, 5.93]-1 study12,630not evaluable NA
Coarctation of aorta3.99 [1.02, 15.54]-1 study1,13714not evaluable NA
Congenital cataract0.24 [0.01, 5.93]-1 study12,630not evaluable NA
Congenital hydronephrosis5.08 [0.26, 98.38]-1 study32,630not evaluable NA
Diaphragmatic hernia0.24 [0.01, 5.93]-1 study12,630not evaluable NA
Down syndrom / Trisomy 211.81 [0.35, 9.36]-1 study72,630not evaluable NA
Eye, ear, face and neck malformations1.18 [0.89, 1.56]-1 study9,49312,891not evaluable NA
Gastroschisis2.43 [0.52, 11.40]-1 study1,39413not evaluable NA
Hypospadias2.17 [0.09, 53.42]-1 study12,630not evaluable NA
Intestinal malrotation0.24 [0.03, 2.32]-1 study42,630not evaluable NA
Multicystic renal dysplasia0.72 [0.05, 11.59]-1 study22,630not evaluable NA
Oesophageal atresia with or without tracheo-oesophageal fistula3.63 [0.17, 75.58]-1 study22,630not evaluable NA
Oro-facial clefts1.23 [0.78, 1.93]-1 study3,46512,891not evaluable NA
Other congenital malformations (Q80 to Q99)1.25 [0.96, 1.62]-1 study10,07912,891not evaluable NA
Patent ductus arterious7.99 [0.44, 144.53]-1 study52,630not evaluable NA
Pulmonary artery stenosis0.24 [0.01, 5.93]-1 study12,630not evaluable NA
Pulmonary valve stenosis2.15 [0.46, 10.07]-1 study1,51713not evaluable NA
Skeletal dysplasia0.24 [0.01, 5.93]-1 study12,630not evaluable NA
Spina bifida3.63 [0.17, 75.58]-1 study22,630not evaluable NA
Sturge-Weber syndrome2.17 [0.09, 53.42]-1 study12,630not evaluable NA
Syndactyly2.18 [0.23, 20.93]-1 study42,630not evaluable NA
Tetralogy of Fallot3.63 [0.17, 75.58]-1 study22,630not evaluable NA
Transposition of the great vessels0.24 [0.01, 5.93]-1 study12,630not evaluable NA
Ventricular septal defect1.12 [0.52, 2.40]-1 study282,630not evaluable NA

Growth parameters and prematurity
Adverse outcome VerdictOR 95%CII2k No. casesNo. exposedpublication biasROB???
Preterm (< 37 weeks)0.95 [0.78, 1.16]3%11 studies6392,427low NA
Low birth weight (< 2500g)1.34 [0.78, 2.32]55%4 studies3071,324not evaluable NA
Small for gestational age (weight)1.06 [0.86, 1.30]0%3 studies5601,400not evaluable NA
Large for gestational age (weight)0.96 [0.60, 1.55]-1 study80586not evaluable NA
Very preterm (28 to 32 weeks)2.01 [0.08, 51.30]-1 study141not evaluable NA
Small for gestational age (length)--0 study
Small head circumference for gestational age--0 study

Maternal consequences
Adverse outcome VerdictOR 95%CII2k No. casesNo. exposedpublication biasROB???
Caesarean2.26 [0.69, 7.45]-1 study2543not evaluable NA
Maternal liver disorder / failure during pregnancy--0 study
Preeclampsia1.13 [0.13, 10.01]0%2 studies4310not evaluable NA
Gestational diabete0.38 [0.02, 9.46]-1 study1176not evaluable NA

Neonatal disorders
Adverse outcome VerdictOR 95%CII2k No. casesNo. exposedpublication biasROB???
Goiter2.03 [0.18, 23.21]57%3 studies27170not evaluable NA
Hypothyroidism (fetal/neonatal)2.54 [0.51, 12.61]6%4 studies11346not evaluable NA
Hyperthyroidism / Thyrotoxicosis (fetal/neonatal)3.27 [0.40, 26.43]40%3 studies15204not evaluable NA
Neonatal hyperthyrotropinemia3.02 [1.04, 8.78]-1 study18111not evaluable NA
Neonatal medical care1.23 [0.92, 1.65]-1 study219586not evaluable NA
Hearing loss / Auditory deficit2.17 [0.09, 53.42]-1 study12,630not evaluable NA
Neonatal death--0 study
Neonatal disorders (as a whole)1.74 [0.31, 9.67]-1 study741not evaluable NA

Intrauterine deaths
Adverse outcome VerdictOR 95%CII2k No. casesNo. exposedpublication biasROB???
Early intrauterine death (< 22 weeks)1.89 [0.68, 5.24]85%4 studies5803,399not evaluable NA
Intrauterine deaths (as a whole)1.41 [0.88, 2.25]0%5 studies86435not evaluable NA
Elective termination of pregnancy1.97 [1.17, 3.33]0%3 studies993,295not evaluable NA
Late intrauterine deaths (> 22 weeks)0.20 [0.01, 6.47]74%2 studies9167not evaluable NA
Perinatal death0.76 [0.36, 1.56]0%3 studies293,350not evaluable NA
Ectopic pregnancy--0 study

Neuro-developmental disorders
Adverse outcome VerdictOR 95%CII2k No. casesNo. exposedpublication biasROB???
Neuro-developmental disorders (as a whole)5.34 [2.17, 13.10]-1 study69220not evaluable NA

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