metaPreg - Hydroxychloroquine during pregnancy

Hydroxychloroquine

Table Graphic exposition period:

Adverse outcome	Verdict	OR 95%CI	I2	k	No. cases	No. exposed	publication bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)		1.58 [0.89, 2.81]	30%	8 studies	5,074	614	not evaluable
Major congenital malformations		1.82 [0.83, 4.00]	44%	4 studies	5,041	434	not evaluable
Congenital heart defects		2.54 [0.60, 10.83]	0%	2 studies	12	220	not evaluable
18 non statistically significant endpoints reported in only one study
Growth parameters and prematurity
Adverse outcome	Verdict	OR 95%CI	I2	k	No. cases	No. exposed	publication bias
Preterm (< 37 weeks)		1.04 [0.71, 1.52]	69%	16 studies	15,848	976	low
Small for gestational age (weight)		0.76 [0.49, 1.20]	57%	12 studies	1,152	591	low
Very preterm (28 to 32 weeks)		0.45 [0.20, 1.01]	0%	3 studies	29	146	not evaluable
Low birth weight (< 2500g)		0.39 [0.22, 0.69]	0%	2 studies	73	150	not evaluable
2 non statistically significant endpoints reported in only one study
Maternal consequences
Adverse outcome	Verdict	OR 95%CI	I2	k	No. cases	No. exposed	publication bias
Preeclampsia		0.52 [0.18, 1.50]	58%	5 studies	67	295	not evaluable
Caesarean		0.57 [0.33, 1.00]	0%	2 studies	116	104	not evaluable
Gestational diabete		1.17 [0.57, 2.37]	0%	3 studies	35	220	not evaluable
Abruptio placentae		1.14 [0.08, 16.11]	51%	2 studies	8	114	not evaluable
Oligohydramnios / Polyhydramnios		0.54 [0.15, 1.96]	0%	2 studies	15	118	not evaluable
Assisted deliveries (forceps, vacuum, ...)		-	-	0 study
Maternal consequences (as a whole)		0.32 [0.14, 0.72]	-	1 study	35	94	not evaluable
3 non statistically significant endpoints reported in only one study
Neonatal disorders
Adverse outcome	Verdict	OR 95%CI	I2	k	No. cases	No. exposed	publication bias
Eye deficiency / Visual abnormality		1.19 [0.16, 8.63]	0%	4 studies		205	not evaluable
Neonatal disorders (as a whole)		1.44 [0.63, 3.25]	0%	3 studies	26	241	not evaluable
Hearing loss / Auditory deficit		1.12 [0.11, 11.06]	0%	3 studies		174	not evaluable
Neonatal death		1.07 [0.20, 5.60]	0%	3 studies	6	110	not evaluable
Fetal distress		0.83 [0.42, 1.66]	0%	2 studies	52	62	not evaluable
Low Apgar score (< 7) (at 5 min)		0.74 [0.21, 2.64]	0%	2 studies	12	110	not evaluable
Neonatal immune dysfunction		-	-	0 study
3 non statistically significant endpoints reported in only one study
Long term consequences
Adverse outcome	Verdict	OR 95%CI	I2	k	No. cases	No. exposed	publication bias
Intrauterine deaths
Adverse outcome	Verdict	OR 95%CI	I2	k	No. cases	No. exposed	publication bias
Late intrauterine deaths (> 22 weeks)		0.82 [0.48, 1.39]	0%	12 studies	76	941	low
Early intrauterine death (< 22 weeks)		1.11 [0.70, 1.76]	50%	12 studies	265	801	low
Intrauterine deaths (as a whole)		0.63 [0.41, 0.97]	38%	9 studies	631	607	not evaluable
Elective termination of pregnancy		2.36 [0.87, 6.44]	0%	2 studies	16	156	not evaluable
1 non statistically significant endpoints reported in only one study