Hydroxychloroquine

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
All congenital malformations (majors, minors, majors and minors, or unspecified)1.58 [0.89, 2.81]30%8 studies5,074614not evaluable
Major congenital malformations1.82 [0.83, 4.00]44%4 studies5,041434not evaluable
Congenital heart defects2.54 [0.60, 10.83]0%2 studies12220not evaluable
18 non statistically significant endpoints reported in only one study

Growth parameters and prematurity
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Preterm (< 37 weeks)1.04 [0.71, 1.52]69%16 studies15,848976low
Small for gestational age (weight)0.76 [0.49, 1.20]57%12 studies1,152591low
Very preterm (28 to 32 weeks)0.45 [0.20, 1.01]0%3 studies29146not evaluable
Low birth weight (< 2500g)0.39 [0.22, 0.69]0%2 studies73150not evaluable
2 non statistically significant endpoints reported in only one study

Maternal consequences
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Preeclampsia0.52 [0.18, 1.50]58%5 studies67295not evaluable
Caesarean0.57 [0.33, 1.00]0%2 studies116104not evaluable
Gestational diabete1.17 [0.57, 2.37]0%3 studies35220not evaluable
Abruptio placentae1.14 [0.08, 16.11]51%2 studies8114not evaluable
Oligohydramnios / Polyhydramnios0.54 [0.15, 1.96]0%2 studies15118not evaluable
Assisted deliveries (forceps, vacuum, ...)--0 study
Maternal consequences (as a whole)0.32 [0.14, 0.72]-1 study3594not evaluable
3 non statistically significant endpoints reported in only one study

Neonatal disorders
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Eye deficiency / Visual abnormality1.19 [0.16, 8.63]0%4 studies205not evaluable
Neonatal disorders (as a whole)1.44 [0.63, 3.25]0%3 studies26241not evaluable
Hearing loss / Auditory deficit1.12 [0.11, 11.06]0%3 studies174not evaluable
Neonatal death1.07 [0.20, 5.60]0%3 studies6110not evaluable
Fetal distress0.83 [0.42, 1.66]0%2 studies5262not evaluable
Low Apgar score (< 7) (at 5 min)0.74 [0.21, 2.64]0%2 studies12110not evaluable
Neonatal immune dysfunction--0 study
3 non statistically significant endpoints reported in only one study

Long term consequences
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias

Intrauterine deaths
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Late intrauterine deaths (> 22 weeks)0.82 [0.48, 1.39]0%12 studies76941low
Early intrauterine death (< 22 weeks)1.11 [0.70, 1.76]50%12 studies265801low
Intrauterine deaths (as a whole)0.63 [0.41, 0.97]38%9 studies631607not evaluable
Elective termination of pregnancy2.36 [0.87, 6.44]0%2 studies16156not evaluable
1 non statistically significant endpoints reported in only one study