Carbimazole, Thiamazole (Methimazole)

Omphalocele

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8483
R27811		 Yoshihara (Controls exposed to PTU), 2021 Omphalocele 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 4.79 [0.22;102.66] C
excluded (control group) 		0/23   2/541 2 23
ref
S8482
R27789		 Yoshihara (Controls unexposed, sick), 2021 Omphalocele 1st trimester retrospective cohort unexposed, sick Adjustment: No 2.99 [0.15;59.73] C 0/23   3/475 3 23
ref
S3353
R5980		 Yoshihara (control exposed to PTU), 2012 Omphalocele 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 14.85 [0.84;263.84] C
excluded (control group) 		6/1,231   0/1,399 6 1,231
ref
S3350
R5843		 Yoshihara (control unexposed, sick), 2012 Omphalocele 1st trimester retrospective cohort unexposed, sick Adjustment: No 20.23 [1.14;359.44] C 6/1,231   0/1,906 6 1,231
ref
S3379
R6253		 Clementi, 2010 Omphalocele 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 10.40 [2.90;37.26] 6/80   148/18,051 154 80
ref
Total 3 studies 9.70 [3.27;28.78] 163 1,334
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (Controls unexposed, sick), 2021Yoshihara, 2021 1 2.99[0.15; 59.73]32313%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: moderate Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 2 20.23[1.14; 359.44]61,23114%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Clementi, 2010Clementi, 2010 10.40[2.90; 37.26]1548073%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: critical Total (3 studies) I2 = 0% 9.70[3.27; 28.78]1631,3340.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 8.08[1.02; 64.32]91,2540%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 case control studiescase control studies 10.40[2.90; 37.28]15480 -NAClementi, 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 10.40[2.90; 37.28]15480 -NAClementi, 2010 1 unexposed, sickunexposed, sick 8.08[1.02; 64.32]91,2540%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 Tags Adjustment   - No  - No 8.08[1.02; 64.32]91,2540%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2   - Yes  - Yes 10.40[2.90; 37.28]15480 -NAClementi, 2010 1 All studiesAll studies 9.70[3.27; 28.78]1631,3340%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 Clementi, 2010 30.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3353, 8483

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale10.40[2.90; 37.28]15480 -NAClementi, 2010 1 unexposed, sick controlsunexposed, sick controls 8.08[1.02; 64.32]91,2540%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 8.74[1.07; 71.21]81,2540%NAYoshihara (Controls exposed to PTU), 2021 Yoshihara (control exposed to PTU), 2012 20.510.01.0