Thiouracil, propylthiouracil, benzylthiouracil

Ano-rectal atresia and stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8484
R27844		 Yoshihara (Controls exposed to MMI), 2021 Aproctia 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.04 [0.00;2.15] C
excluded (control group) 		0/541   0/23 0 541
ref
S8481
R27778		 Yoshihara (Controls unexposed, sick), 2021 Aproctia 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.29 [0.01;7.19] C 0/541   1/475 1 541
ref
S3359
R6106		 Howley, 2017 Ano-rectal atresia 1st trimester case control unexposed, disease free Adjustment: No 8.62 [1.71;40.10] 4/14   1,048/12,338 1,052 14
ref
S3355
R6075		 Yoshihara (control exposed to MMI), 2012 Imperforate anus 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.88 [0.05;14.08] C
excluded (control group) 		1/1,399   1/1,231 2 1,399
ref
S3354
R6032		 Yoshihara (control unexposed, sick), 2012 Imperforate anus 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.68 [0.06;7.52] C 1/1,399   2/1,906 3 1,399
ref
Total 3 studies 1.62 [0.19;14.09] 1,056 1,954
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (Controls unexposed, sick), 2021Yoshihara, 2021 1 0.29[0.01; 7.19]154125%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: moderate Howley, 2017Howley, 2017 8.62[1.71; 40.10]1,0521442%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 2 0.68[0.06; 7.52]31,39933%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 62% 1.62[0.19; 14.09]1,0561,9540.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.50[0.07; 3.43]41,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 case control studiescase control studies 8.62[1.78; 41.74]1,05214 -NAHowley, 2017 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 8.62[1.78; 41.74]1,05214 -NAHowley, 2017 1 unexposed, sickunexposed, sick 0.50[0.07; 3.43]41,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 Tags Adjustment   - No  - No 1.62[0.19; 14.09]1,0561,95462%NAYoshihara (Controls unexposed, sick), 2021 Howley, 2017 Yoshihara (control unexposed, sick), 2012 3 All studiesAll studies 1.62[0.19; 14.09]1,0561,95462%NAYoshihara (Controls unexposed, sick), 2021 Howley, 2017 Yoshihara (control unexposed, sick), 2012 30.120.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3355, 8484

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 8.62[1.78; 41.74]1,05214 -NAHowley, 2017 1 unexposed, sick controlsunexposed, sick controls 0.50[0.07; 3.43]41,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.27[0.01; 4.95]21,94035%NAYoshihara (Controls exposed to MMI), 2021 Yoshihara (control exposed to MMI), 2012 20.510.01.0