Thiouracil, propylthiouracil, benzylthiouracil

Ano-rectal atresia and stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3359
R6106		 Howley, 2017 Ano-rectal atresia 1st trimester case control unexposed, disease free Adjustment: No 8.62 [1.71;40.10] 4/14   1,048/12,338 1,052 14
ref
Total 1 studies 8.62 [1.78;41.74] 1,052 14
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Howley, 2017Howley, 2017 8.62[1.71; 40.10]1,052140%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 8.62[1.78; 41.74]1,05214 -NAHowley, 2017 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 8.62[1.78; 41.74]1,05214 -NAHowley, 2017 1 Tags Adjustment   - No  - No 8.62[1.78; 41.74]1,05214 -NAHowley, 2017 1 All studiesAll studies 8.62[1.78; 41.74]1,05214 -NAHowley, 2017 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 8.62[1.78; 41.74]1,05214 -NAHowley, 2017 1 unexposed, sick controlsunexposed, sick controls 0.50[0.07; 3.43]41,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.27[0.01; 4.95]21,94035%NAYoshihara (Controls exposed to MMI), 2021 Yoshihara (control exposed to MMI), 2012 20.510.01.0