Thiouracil, propylthiouracil, benzylthiouracil

Severe congenital heart defect

id	Study   Auto Korelitz (control exposed to MMI), 2013Korelitz (control exposed to MMI), 2013Korelitz (control unexposed, disease free), 2013Korelitz (control unexposed, sick), 2013Yoshihara (control exposed to MMI), 2012Yoshihara (control unexposed, sick), 2012Clementi, 2010	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S3387 R6308	Korelitz (control exposed to MMI), 2013	Complex congenital heart disease	3 months (or more) before pregnancy or during pregnancy	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No	3.22 [0.19;54.55] C excluded (control group)	13/915   0/108	13	915		ref
S8718 R29459	Korelitz (control exposed to MMI), 2013	Complex congenital heart disease	3 months (or more) before pregnancy or during pregnancy	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No	3.22 [0.19;54.55] C excluded (control group)	13/915   0/108	13	915		ref
S3388 R6316	Korelitz (control unexposed, disease free), 2013	Complex congenital heart disease	3 months (or more) before pregnancy or during pregnancy	retrospective cohort (claims database)	unexposed, disease free excluded	Adjustment: No	2.37 [1.37;4.11] C excluded (control group)	13/915   3,832/634,858	3,845	915		ref
S3389 R6324	Korelitz (control unexposed, sick), 2013	Complex congenital heart disease	3 months (or more) before pregnancy or during pregnancy excluded	retrospective cohort (claims database)	unexposed, sick	Adjustment: No	1.78 [0.91;3.48] C excluded (exposition period)	13/915   26/3,236	39	915		ref
S3355 R6072	Yoshihara (control exposed to MMI), 2012	Congenital cardiovascular deformity	1st trimester	retrospective cohort	exposed to other treatment, sick excluded	Adjustment: No	0.88 [0.02;44.38] C excluded (control group)	0/1,399   0/1,231	0	1,399		ref
S3354 R6029	Yoshihara (control unexposed, sick), 2012	Congenital cardiovascular deformity	1st trimester	retrospective cohort	unexposed, sick	Adjustment: No	0.19 [0.01;3.77] C	0/1,399   3/1,906	3	1,399		ref
S3380 R6260	Clementi, 2010	Cardiac outflow tract defects (OTD)	1st trimester	case control	unexposed (general population or NOS)	Adjustment: Yes	4.12 [1.06;16.06]	5/47   731/18,084	736	47		ref
					Total	2 studies	1.20 [0.06;22.67]		739	1,446
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 3355, 3387, 8718, 3388