Thiouracil, propylthiouracil, benzylthiouracil

Severe congenital heart defect

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3387
R6308
Korelitz (control exposed to MMI), 2013 Complex congenital heart disease 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 3.22 [0.19;54.55] C
excluded (control group)
13/915   0/108 13 915
ref
S8718
R29459
Korelitz (control exposed to MMI), 2013 Complex congenital heart disease 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 3.22 [0.19;54.55] C
excluded (control group)
13/915   0/108 13 915
ref
S3388
R6316
Korelitz (control unexposed, disease free), 2013 Complex congenital heart disease 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 2.37 [1.37;4.11] C
excluded (control group)
13/915   3,832/634,858 3,845 915
ref
S3389
R6324
Korelitz (control unexposed, sick), 2013 Complex congenital heart disease 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 1.78 [0.91;3.48] C
excluded (exposition period)
13/915   26/3,236 39 915
ref
S3355
R6072
Yoshihara (control exposed to MMI), 2012 Congenital cardiovascular deformity 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.88 [0.02;44.38] C
excluded (control group)
0/1,399   0/1,231 0 1,399
ref
S3354
R6029
Yoshihara (control unexposed, sick), 2012 Congenital cardiovascular deformity 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.19 [0.01;3.77] C 0/1,399   3/1,906 3 1,399
ref
S3380
R6260
Clementi, 2010 Cardiac outflow tract defects (OTD) 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 4.12 [1.06;16.06] 5/47   731/18,084 736 47
ref
Total 2 studies 1.20 [0.06;22.67] 739 1,446
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 1 0.19[0.01; 3.77]31,39940%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Clementi, 2010Clementi, 2010 4.12[1.06; 16.06]7364760%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: critical Total (2 studies) I2 = 70% 1.20[0.06; 22.67]7391,4460.010.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.19[0.01; 3.77]31,399 -NAYoshihara (control unexposed, sick), 2012 1 case control studiescase control studies 4.12[1.06; 16.04]73647 -NAClementi, 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 4.12[1.06; 16.04]73647 -NAClementi, 2010 1 unexposed, sickunexposed, sick 0.19[0.01; 3.77]31,399 -NAYoshihara (control unexposed, sick), 2012 1 Tags Adjustment   - No  - No 0.19[0.01; 3.77]31,399 -NAYoshihara (control unexposed, sick), 2012 1   - Yes  - Yes 4.12[1.06; 16.04]73647 -NAClementi, 2010 1 All studiesAll studies 1.20[0.06; 22.67]7391,44670%NAYoshihara (control unexposed, sick), 2012 Clementi, 2010 20.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3355, 8718, 3387, 3388

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.12[1.06; 16.04]73647 -NAClementi, 2010 1 unexposed, sick controlsunexposed, sick controls Out of scale0.19[0.01; 3.77]31,399 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.88[0.02; 44.38]-1,399 -NAYoshihara (control exposed to MMI), 2012 10.510.01.0