Valproate (Epilepsy) updated on 04-22-2025

Behavioral disorders: Diagnosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15877
R65466		 Dreier (Valproate) (Epilepsy) (Controls exposed to LTG), 2023 Oppositional defiant disorder and conduct disorder - Corresponding ICD-10 F-chapter - Up to 22 years of age during pregnancy (anytime or not specified) population based cohort propective exposed to other treatment, sick excluded Adjustment: No 2.92 [1.41;6.05] C
excluded (control group) 		15/1,952   14/5,288 29 1,952
ref
S15878
R65480		 Dreier (Valproate) (Epilepsy) (Controls unexposed, sick), 2023 Oppositional defiant disorder and conduct disorder - Corresponding ICD-10 F-chapter - Up to 22 years of age during pregnancy (anytime or not specified) population based cohort propective unexposed, sick Adjustment: Yes 0.79 [0.43;1.46] 15/1,952   110/22,203 125 1,952
ref
Total 1 studies 0.79 [0.43;1.46] 125 1,952
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dreier (Valproate) (Epilepsy) (Controls unexposed, sick), 2023Dreier, 2023 1 0.79[0.43; 1.46]1251,9520%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate) (Epilepsy) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.79[0.43; 1.46]1251,952 -NADreier (Valproate) (Epilepsy) (Controls unexposed, sick), 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.79[0.43; 1.46]1251,952 -NADreier (Valproate) (Epilepsy) (Controls unexposed, sick), 2023 1 Tags Adjustment   - Yes  - Yes 0.79[0.43; 1.46]1251,952 -NADreier (Valproate) (Epilepsy) (Controls unexposed, sick), 2023 1 All studiesAll studies 0.79[0.43; 1.46]1251,952 -NADreier (Valproate) (Epilepsy) (Controls unexposed, sick), 2023 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 15877

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.79[0.43; 1.46]1251,952 -NADreier (Valproate) (Epilepsy) (Controls unexposed, sick), 2023 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.92[1.41; 6.05]291,952 -NADreier (Valproate) (Epilepsy) (Controls exposed to LTG), 2023 10.510.01.0