Pregabalin (All indications) - Medication and Pregnancy KB

Pregabalin (All indications) updated on 04-22-2025

Preterm (< 37 weeks)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17225 R72131	Kaskal (Indications NOS), 2024	Preterm deliveries (birth <37 weeks)	during pregnancy (anytime or not specified)	cohort	unexposed (general population or NOS)	Adjustment: No	3.77 [1.00;14.20] ^C	5/27 5/88	10	27		ref
S15251 R62708	Dudukina (Controls exposed to LTG) (Mixed indications), 2023	Preterm birth (gestational age <37 weeks)	3 months (or more) before pregnancy or during pregnancy	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: Yes	0.94 [0.79;1.11] excluded (control group)	188/2,414 540/7,243	728	2,414		ref
S15252 R62729	Dudukina (Controls unexposed, NOS) (Mixed indications), 2023	Preterm birth (gestational age <37 weeks)	3 months (or more) before pregnancy or during pregnancy excluded	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes	1.15 [1.00;1.32] excluded (exposition period)	188/2,414 151,114/3,009,386	151,302	2,414		ref
S10100 R36794	Coste (Controls exposed to Lamotrigine, sick) (Mixed indications), 2020	Gestational age at birth (< 37 WA)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No	1.09 [0.85;1.39] ^C excluded (control group)	110/1,627 182/2,916	292	1,627		ref
S8541 R28338	Coste (Controls unexposed, NOS) (Mixed indications), 2020	Gestational age at birth (< 37 WA)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No	1.29 [1.06;1.56] ^C	110/1,627 91,255/1,710,441	91,365	1,627		ref
S18025 R75959	Margulis (Pregabalin) (Indications other than epilepsy), 2019	Preterm birth (delivery before 37 completed weeks)	during pregnancy (anytime or not specified)	population based cohort retrospective	exposed to other treatment, sick	Adjustment: Yes	1.50 [0.90;2.50]	-/492 -/1,787	-	492		ref
S8537 R28309	Kilic (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014	Preterm (< 37 weeks)	during pregnancy (anytime or not specified)	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No	2.88 [0.78;10.68] ^C excluded (control group)	3/13 83/880	86	13		ref
S8538 R28312	Kilic (Controls unexposed NOS) (Mixed indications), 2014	Preterm (< 37 weeks)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed (general population or NOS) excluded	Adjustment: No	5.68 [1.56;20.63] ^C excluded (control group)	3/13 33,974/676,834	33,977	13		ref
S8539 R28315	Kilic (Controls unexposed, sick) (Mixed indications), 2014	Preterm (< 37 weeks)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, sick	Adjustment: No Controls: epilepsy indication	3.85 [1.05;14.04] ^C	3/13 383/5,296	386	13		ref
					Total	4 studies	1.60 [1.08;2.38]		91,761	2,159
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Indications NOS; 2: Controls unexposed, NOS) (Mixed indications; 3: Pregabalin) (Indications other than epilepsy; 4: Controls unexposed, sick) (Mixed indications;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Sub-groups analysis using all included studies

excluded 8537, 8538, 10100, 15251