Triptans

All congenital malformations (majors, minors, majors and minors, or unspecified)

id	Study   Auto Spielmann (Control mainly exposed other treatments, sick), 2017Spielmann (Control unexposed, disease free), 2017Nezvalová-Henriksen (Control unexposed, disease free), 2013Nezvalová-Henriksen (Control unexposed, sick), 2013Bérard, 2012Källén (control exposed to ergots), 2011Källén (control unexposed, disease free), 2011Shuhaiber - Sumatriptan (Control exposed to other treatments), 1998Shuhaiber - Sumatriptan (Control unexposed, disease free), 1998	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S850 R11398	Bérard, 2012	Major congenital malformations	during pregnancy (anytime or not specified) excluded	nested case control	unexposed, disease free	Adjustment: Yes	1.49 [0.89;2.52] excluded (exposition period)	18/139   4,698/59,568	4,716	139		ref
					Total	0 studies	NaN [NaN;NaN]		0	0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis