Diltiazem (versus unexposed)

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Weber-Schoendorfer 2008	Finland, France, Germany, Israel, Italy, the Netherlands. 1986 - 2003 prospective cohort	A multicenter (n = 11), prospective observational study of the European Network of Teratology Information Services (ENTIS).	Pregnant women with first- trimester exposure to Diltiazem.	unexposed (general population or NOS) Pregnant women who had been counseled during pregnancy about exposures known to be non-teratogenic.	at least 1st trimester	41 / 806
Weber-Schoendorfer 2008			A similarly structured questionnaire was used by all the centres to record the following data at the first contact during (early) pregnancy before the pregnancy outcome was known, including details of drug exposure (timing in pregnancy, dose, and duration).		at least 1st trimester	41 / 806

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;