Isradipine (versus exposed to other treatments)

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Darcie 2004	Brazil 1994 - 1997 prospective cohort	A randomized, longitudinal, prospective study conducting at the Neonatal Pediatrics Service, Faculty of Medicine, University of São Paulo.	Newborns of hypertensive mothers treated with isradipine (5 mg twice a day) for at least 2 weeks before the delivery.	exposed to other treatment, sick Newborns of hypertensive mothers treated with atenolol (50 mg twice a day) for at least 2 weeks before the delivery.	late pregnancy	39 / 40	Study considered as a prospective cohort because no precision indicating that a randomization was carried out.
Darcie 2004	Brazil 1994 - 1997 prospective cohort		This was a randomized, longitudinal, prospective study comparing 3 groups of patients according to the type of maternal treatment. => Not otherwise specified => Considered as a prospective cohort because no precision indicating that a randomization was carried out.		late pregnancy	39 / 40

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;