Granisetron - Medication and Pregnancy KB

Granisetron

Exposed non-exposed, cohort studies

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Shapira 2020	Israel 2013 - 2015 retrospective cohort	Medical records of a single tertiary medical center.	Patients who were exposed to granisetron.	unexposed, sick Patients without exposure to granisetron.	1st trimester, during pregnancy (anytime or not specified)	100 / 108	Cases diagnosed with chromosomal aberrations and cases of pregestational diabetes were excluded from the study.
Shapira 2020	Israel 2013 - 2015 retrospective cohort	Medical records of a single tertiary medical center.	Medical records.		1st trimester, during pregnancy (anytime or not specified)	100 / 108

Case-control studies

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Fejzo 2015	USA 2007 - 2011 case control	A part of a larger investigation evaluating the 44 genetics and epidemiology of Hyperemesis gravidarum (HG)	Children exposed to hyperemesis gravidarum (HG) with neurodevelopmental delay.	Children exposed to hyperemesis gravidarum (HG) with a good outcome.	Participants were asked to submit their medical records and complete an online survey regarding treatment.	during pregnancy (anytime or not specified)	138 / 174	Main analysis: case control related to the impact of the HG illness (treated or not) on child outcomes. Then impact of 37 medications/treatments (1st and/or 2nd trimester) on child outcome was investigated (none was significantly associated with delay).
Fejzo 2015	USA 2007 - 2011 case control		Participants were asked to submit their medical records and complete an online survey regarding outcomes. A follow-up survey was administered on the diagnosis of childhood emotional, behavioral, and learning disorders.			during pregnancy (anytime or not specified)	138 / 174
Fejzo 2013	USA 2007 - 2011 case control	A part of a larger investigation evaluating the genetics and epidemiology of Hyperemesis gravidarum (HG).	Pregnant women with hyperemesis gravidarum (HG) who have negative outcomes (birth weight less than 10%, perinatal mortality, and/or preterm birth (<37 weeks)).	Pregnant women with hyperemesis gravidarum (HG) who have positive outcomes.	Participants were asked to submit their medical records and complete an online surveyregarding treatment. The majority of participants, both cases and controls, joined the study and began the survey during their pregnancies.	during pregnancy (anytime or not specified)	43 / 211	Comparison of use of various medications/treatments in the two groups (43 HG participants with an adverse outcome compared to 211 HG participants with a good outcome).
Fejzo 2013	USA 2007 - 2011 case control		Participants were asked to submit their medical records and complete an online surveyregarding outcomes. The majority of participants, both cases and controls, were automatically prompted to complete the survey on outcome following their due date.			during pregnancy (anytime or not specified)	43 / 211

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;

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