Peginterferon

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Beauverd 2016	United Kingdom 2013 - 2015 retrospective cohort		Pregnancies in essential thrombocythemia (ET) women treated with Pegylated interferon alpha-2a (PEG-IFN).	exposed to other treatment, sick Previous pregnancies in the same women without use of Pegylated interferon alpha-2a (PEG-IFN).	during pregnancy (anytime or not specified)	10 / 9	Other treatments in control group: low dose aspirin, ow molecular weight heparin (LMWH), IFN.
Beauverd 2016	United Kingdom 2013 - 2015 retrospective cohort		Demographics, past medical and obstetric history, previous thrombosis and hemorrhage, previous treatment, disease characteristics at diagnosis and during pregnancy were retrospectively extracted from patients’ notes.		during pregnancy (anytime or not specified)	10 / 9

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;