Tinidazole

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Czeizel 2003	Hungary 1980 - 1996 case control	The Hungarian Case–Control Surveillance of Congenital Abnormalities.	Newborns with isolated congenital abnormalities (CAs) and multiple CAs selected from the Hungarian Congenital Abnormality Registry.	Two newborn infants without congenital abnormalities (CAs) selected for every case from the National Birth Registry of the Central Statistical Office.	Exposure data obtained prospectively through antenatal care logbooks and other medical records, and retrospectively by questionnaires completed by mothers. Finally all non-respondent case and 200 non-respondent control families were visited at home by regional nurses to obtain necessary data.	1st trimester, during pregnancy (anytime or not specified)	22843 / 38151
Czeizel 2003	Hungary 1980 - 1996 case control		Not specified.			1st trimester, during pregnancy (anytime or not specified)	22843 / 38151

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;