Clonidine (versus unexposed)

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Huisjes 1986	The Netherlands 1974 - 1981 retrospective cohort	The database of the Obstetrical Department of the Groningen University Hospital, The Netherlands.	Pregnant women who had been treated for hypertension or superimposed preeclampsia with clonidine only.	unexposed, sick Non-treated hypertensive gravidae matched for diastolic blood pressure during pregnancy, and sex, birthweight and gestational age of the children.	during pregnancy (anytime or not specified)	22 / 22	The start of the clonidine medication varied from before conception to 35 weeks gestational age and it was continued until delivery in all cases, dosages ranged from twice 75 microg to three times 150 microg.
Huisjes 1986	The Netherlands 1974 - 1981 retrospective cohort		Not specified.		during pregnancy (anytime or not specified)	22 / 22

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;