Carteolol (versus unexposed)

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Ishibashi 2017	Japan 2000 - 2016 retrospective cohort	15 Japanese institutions.	Pregnancies in long QT patients with Carteolol therapy.	unexposed, sick Pregnancies in long QT patients without β-blocker therapy.	during pregnancy (anytime or not specified)	2 / 94	Exposure: 1 carteolol (15mg/day, 0.25mg/ kg/day) in the text but 2 in the Supplemental Table2. The considered number of exposure was 2 because it corresponds to the 'right' sum of exposure to beta-blockers.
Ishibashi 2017	Japan 2000 - 2016 retrospective cohort	15 Japanese institutions.	All data were collected with checking their maternity record book.		during pregnancy (anytime or not specified)	2 / 94

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;