Norsuximidium (Epilepsy = ALL)

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Czeizel (Norsuximidium) 1992	Hungary 1980 - 1987 case control	The Hungarian Case-Control Surveillance of Congenital Anomalies.	Children affected with congenital abnormalities born from treated or untreated mothers.	Children without congenital abnormalities born from treated or untreated mothers.	Mothers were mailed a questionnaire requested information on medicinal products taken during pregnancy and to send their prenatal maternity logbook which related drug prescriptions. Regional nurses were asked to visit and question the non-respondent.	throughout pregnancy	100 / 54	The study design was partly completed thanks to the reference [6] cited in the publication (as the definition of congenital abnormalities).
Czeizel (Norsuximidium) 1992	Hungary 1980 - 1987 case control		Notification of cases with congenital abnormality is mandatory for physicians to the HCAR. Pathologists sent autopsy report for stillbirths and infant deaths cases. Prenatally diagnosed and electively terminated malformed fetuses have also been registered.			throughout pregnancy	100 / 54

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;