Vortioxetine

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Laspro 2024	USA 2013 - 2023 nested case control	EPIC Cosmos, a database incorporating health information of 180 million patients, throughout the United States from approximately 180 US institutions utilizing EPIC medical records.	Newborns with oral clefts (ICD 10 codes Q35 or Q36 or Q37).	Newborns without oral clefts.	Gestational medication use was identified by medications, prescribed, provider-administered, or reported use by mothers at any point during pregnancy.	during pregnancy (anytime or not specified)	12098 / -9	P-values were calculated, while to account for multiple testing (693 hypotheses) Benjamini- Hochberg (BH) corrections were performed with a false discovery rate (Q) of 0.05.
Laspro 2024	USA 2013 - 2023 nested case control		Oral cleft cohorts were isolated using a combination of ICD codes, from the EPIC medical records.			during pregnancy (anytime or not specified)	12098 / -9

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;