Timolol (Ocular route only) (versus unexposed)

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Pellegrino 2018	Italy 2003 - 2015 prospective cohort	The “Telefono Rosso”, an Italian Teratology Information Service (TIS).	Pregnant women with glaucoma and treated with topical Timolol monotherapy during the first trimester.	unexposed, disease free Healthy pregnant women with normal singleton pregnancies without significant exposure to any medications considered unsafe.	throughout pregnancy	27 / 187	Twenty-seven women used timolol as monotherapy, one drop (0,2 mg) one time daily and 48 as part of multidrug therapy in association with prostaglandins analogues or carbonic anhydrase inhibitors (dorzolamide, brinzolamide) one drop one time daily.
Pellegrino 2018	Italy 2003 - 2015 prospective cohort		At the time of the call, women treated with topical antiglaucoma medication during the first trimester were interviewed about clinical and pregnancy information.		throughout pregnancy	27 / 187

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;