| Study | Exclusion reasons | Rmk | Reference |
|---|---|---|---|
| Akcelik,, 2015 | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage that is studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Akcelik, Y. Turk. Klinikleri Jinekoloji Obstet. 2015; 25:19-. 10.5336/gynobstet.2014-41444 |
|
| Akbari Sene, 2018 | inadequate or absent control group | EXCLUDED: Pregnancy outcomes of women treated with clomiphene were compared with those treated with letrozole, whose safety in pregnancy is not well established => inadequate control group. |
Akbari Sene J Obstet Gynaecol Res 2018; 44:1036-1041 10.1111/jog.13644 |
| Tulandi, 2006 | inadequate or absent control group | EXCLUDED: Pregnancy outcomes of women treated with clomiphene were compared with those treated with letrozole, whose safety in pregnancy is not well established => inadequate control group. |
Tulandi Fertil Steril 2006; 85:1761-5 10.1016/j.fertnstert.2006.03.014 |
| Wasim, 2024 | inadequate or absent control group | EXCLUDED: Pregnancy outcomes of women treated with clomiphene were compared with those treated with letrozole, whose safety in pregnancy is not well established => inadequate control group. | |
| Moll, 2006 | inadequate or absent control group | EXCLUDED: All women received clomiphene citrate => No adequate control group. | |
| Legro, 2014 | inadequate or absent control group | EXCLUDED: Pregnancy outcomes of women treated with clomiphene were compared with those treated with letrozole, whose safety in pregnancy is not well established => inadequate control group. |
Legro N Engl J Med 2014; 371:119-29 10.1056/NEJMoa1313517 Legro Contemp Clin Trials 2012; 33:470-81 10.1016/j.cct.2011.12.005 |
| Yun, 2018 | inadequate or absent control group | EXCLUDED: Pregnancy outcomes of women treated with clomiphene were compared with those treated with letrozole, whose safety in pregnancy is not well established => inadequate control group. |
Yun Reprod Toxicol 2018; 82:88-93 10.1016/j.reprotox.2018.10.006 |
| Yland, 2022 | inadequate or absent control group | EXCLUDED: Pregnancies outcomes of women treated with clomiphene compared with those in women treated with letrozole, whose safety in pregnancy is not well established => inadequate control group. | |
| Shalom-Paz, 2014 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriages as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Shalom-Paz Gynecol Endocrinol 2014; 30:107-10 10.3109/09513590.2013.860126 |
| Balen, 1993 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Balen Hum Reprod 1993; 8:959-64 10.1093/oxfordjournals.humrep.a138174 |
| Manganiello, 1997 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage outcome studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Manganiello Fertil Steril 1997; 68:405-12 10.1016/s0015-0282(97)00260-4 |
| Kang, 2013 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage that is studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Kang, Y. J. Reprod. Contracept. 2013; 24:10-. 10.1016/S1001-7844(13)60016-4 |
| Akcelik, 2015 | inadequate or absent control group | EXCLUDED: Pregnancy outcomes of women treated with clomiphene compared with those treated with Gonadotropin, whose safety in pregnancy is not well established => inadequate control group. |
Akcelik, Y. Turk. Klinikleri Jinekoloji Obstet. 2015; 25:19-. 10.5336/gynobstet.2014-41444 |
| Huong, 2002 | inadequate or absent control group | EXCLUDED: Study comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Huong Semin Arthritis Rheum 2002; 32:174-88 10.1053/sarh.2002.37212 |
| Diamond, 2015 | inadequate or absent control group | EXCLUDED: Pregnancy outcomes of women treated with clomiphene compared with those treated with Letrozole or with Gonadotropin, whose safety in pregnancy is not well established => inadequate control group. |
Diamond N Engl J Med 2015; 373:1230-40 10.1056/NEJMoa1414827 |
| El Hachem, 2017 | inadequate or absent control group | EXCLUDED: Pregnancy outcomes of women treated with clomiphene compared with those treated with letrozole, whose safety in pregnancy is not well established => inadequate control group. |
El Hachem Gynecol Obstet Invest 2017; 82:481-486 10.1159/000452665 |
| Waanbah, 2021 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage that is studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Waanbah J Obstet Gynaecol Res 2021; 47:3583-3589 10.1111/jog.14926 |
| Wu, 1997 | inadequate or absent control group | EXCLUDED: Pregnancy outcomes of women treated with clomiphene compared with those treated with tamoxifen, whose safety in pregnancy is not well established => inadequate control group. | |
| Eftekhar, 2014 | inadequate or absent control group | EXCLUDED: RCT on the efficacy of clomiphene, including miscarriage that is studied as an efficacy criteria rather than a safety one; and comparing with letrozole, whose safety in pregnancy is not well established => inadequate control group. | |
| Davar, 2006 | inadequate or absent control group | EXCLUDED: RCT on the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one; and comparing with Letrozole, whose safety in pregnancy is not well established => inadequate control group. | |
| Foroozanfard, 2011 | inadequate or absent control group | EXCLUDED: Pregnancy outcomes of women treated with clomiphene compared with those treated with letrozole, whose safety in pregnancy is not well established => inadequate control group. | |
| Ionescu, 2011 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage that is studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. | |
| Khanna, 2013 | inadequate or absent control group | EXCLUDED: Expression of Concern of the Editor. Study on the efficacy of clomiphene, including miscarriage (efficacy aims rather than safety); and comparing with letrozole, whose safety in pregnancy is not well established => inadequate control group. |
Khanna Arch Gynecol Obstet 2013; 287:571-5 10.1007/s00404-012-2579-9 |
| Davar, 2006 | inadequate or absent control group | EXCLUDED: RCT on the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one; and comparing with letrozole, whose safety in pregnancy is not well established => inadequate control group. | |
| Abu Hashim, 2011 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage (efficacy aims rather than safety); and comparing with highly purified urinary FSH (HP-uFSH), whose safety in pregnancy is not well established => inadequate control group. |
Abu Hashim Gynecol Endocrinol 2011; 27:190-6 10.3109/09513590.2010.488771 |
| Kingsland, 1992 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage outcome studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Kingsland Fertil Steril 1992; 57:804-9 10.1016/s0015-0282(16)54962-0 |
| Xiao, 2021 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage outcome studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Xiao, Y.-H. Indian J. Pharm. Sci. 2021; 83:139-. 10.36468/pharmaceutical-sciences.spl.266 |
| Wang, 2008 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one; and comparing with tamoxifen, whose safety in pregnancy is not well established => inadequate control group. |
Wang Reprod Biomed Online 2008; 17:20-6 10.1016/s1472-6483(10)60288-x |
| Yu, 2019 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage outcome, studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Yu J Chin Med Assoc 2019; 82:845-848 10.1097/JCMA.0000000000000177 |
| Seyedoshohadaei, 2012 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage outcome studied as an efficacy criteria rather than a safety one; and comparing with 2 active comparators, whose safety in pregnancy is not well established => inadequate control group. | |
| Chen, 2016 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage outcome, studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. | |
| Check, 2017 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one; and comparing with letrozole whose safety in pregnancy is not well established => inadequate control group. |
Check, J.H. Clin. Exp. Obstet. Gynecol. 2017; 44:180-. 10.12891/ceog3466.2017 |
| Ayaz, 2018 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage outcome, studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Ayaz, R. Turk. J. Obstet. Gynecol. 2018; 15:243-. 10.4274/TJOD.99835 |
| Ganesh, 2009 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage outcome, studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Ganesh J Assist Reprod Genet 2009; 26:19-24 10.1007/s10815-008-9284-4 |
| Moslemizadeh, 2008 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one; and comparing with tamoxifen, whose safety in pregnancy is not well established => inadequate control group. |
Moslemizadeh, N. J. Med. Sci. (Pakistan) 2008; 8:734-. 10.3923/jms.2008.734.738 |
| Kar, 2012 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one; and comparing with letrozole, whose safety in pregnancy is not well established => inadequate control group. | |
| Kumari, 2022 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one; and comparing with Letrozole, whose safety in pregnancy is not well established => inadequate control group. |
Kumari, S. J. Cardiovasc. Dis. Res. 2022; 13:1115-. 10.31838/jc9r.2022.13.08.125 |
| Saunders, 1992 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage, studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Saunders Hum Reprod 1992; 7:1154-8 10.1093/oxfordjournals.humrep.a137812 |
| Singh, 2016 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage, studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Singh J Hum Reprod Sci 2016; 9:159-163 10.4103/0974-1208.192054 |
| Zakherah, 2010 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage outcome, studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Zakherah Int J Gynaecol Obstet 2010; 108:240-3 10.1016/j.ijgo.2009.10.004 |
| Chen, 2016 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage outcome, studied as an efficacy criteria rather than a safety one; and comparing with letrozole, whose safety in pregnancy is not well established => inadequate control group. |
Chen Pak J Med Sci 2016; 32:1434-1438 10.12669/pjms.326.11391 |
| Topçu, 2017 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one; and comparing with tamoxifen whose safety in pregnancy is not well established => inadequate control group. | |
| Siristatidis a, 2017 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage outcome, studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. | |
| Jouan, 2016 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage outcome, studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Jouan Gynecol Endocrinol 2016; 32:807-810 10.1080/09513590.2016.1177012 |
| Lee, 2012 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage outcome that is studied as an efficacy criteria rather than a safety one; and comparing with Letrozole, whose safety in pregnancy is not well established => inadequate control group. | |
| Lin, 2022 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including live birth outcome, studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Lin Front Endocrinol (Lausanne) 2022; 12:780392 10.3389/fendo.2021.780392 |
| Palomba, 2010 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage outcome, studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Palomba Am J Obstet Gynecol 2010; 202:577.e1-8 10.1016/j.ajog.2009.11.042 |
| Najim, 2020 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one; and comparing with Letrozole, whose safety in pregnancy is not well established => inadequate control group. |
Najim, H.D. Ann. Trop. Med. Public Health 2020; 23:1836-. 10.36295/ASRO.2020.231377 |
| Bordewijk, 2023 | inadequate or absent control group | EXCLUDED: Pregnancy outcomes of women treated with clomiphene compared with those treated with an active comparator, whose safety in pregnancy is not well established => inadequate control group. |
Bordewijk Hum Reprod 2023; 38:421-429 10.1093/humrep/deac268 |
| Ege, 2020 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including miscarriage outcome, studied as an efficacy criteria rather than a safety one; and comparing with an active comparator, whose safety in pregnancy is not well established => inadequate control group. | |
| Harira, 2018 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one; and comparing with Letrozole, whose safety in pregnancy is not well established => inadequate control group. |
Harira, M. Middle East Fertil. Soc. J. 2018; 23:384-. 10.1016/j.mefs.2018.05.008 |
| Davar, 2011 | inadequate or absent control group | EXCLUDED: Study on the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one; and comparing with Letrozole, whose safety in pregnancy is not well established => inadequate control group. | |
| Schieve, 2003 | inadequate or absent control group | EXCLUDED: Study assessing the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one (and Gonadotropins only as comparator). |
Schieve Obstet Gynecol 2003; 101:959-67 10.1016/s0029-7844(03)00121-2 |
| Cornel, 1989 | inadequate or absent control group | EXCLUDED: Study did not have a concurrent control group (use of an external control group) => Inadequate control group. | |
| Abu Hashim, 2011 | other reason | EXCLUDED: Retracted article in Pubmed. |
Abu Hashim Arch Gynecol Obstet 2011; 284:1303-9 10.1007/s00404-011-1983-x |
| Badawy c, 2009 | other reason | EXCLUDED: Retracted article in Pubmed. |
Badawy Fertil Steril 2009; 92:860-863 10.1016/j.fertnstert.2007.08.034 |
| Badawy, 2011 | other reason | EXCLUDED: Article retracted in Pubmed. |
Badawy Eur J Obstet Gynecol Reprod Biol 2011; 159:151-154 10.1016/j.ejogrb.2011.07.015 |
| Badawy a, 2009 | other reason | EXCLUDED: Article retracted in Pubmed. |
Badawy Fertil Steril 2009; 92:849-852 10.1016/j.fertnstert.2007.02.062 |
| Badawy b, 2009 | other reason | EXCLUDED: Editor's note of concern due to concerns raised regarding the authenticity of the data presented within the article. |
Badawy Acta Obstet Gynecol Scand 2009; 88:187-91 10.1080/00016340802638199 |
| Badawy, 2010 | other reason | EXCLUDED: Article retracted in Pubmed. |
Badawy J Obstet Gynaecol 2010; 30:617-21 10.3109/01443615.2010.497873 |
| Abu Hashim, 2011 | other reason | EXCLUDED: Editor's note of concern due to concerns raised regarding the authenticity of the data presented within the article |
Abu Hashim J Obstet Gynaecol Res 2011; 37:169-77 10.1111/j.1447-0756.2010.01383.x |
| Abu Hashim, 2012 | other reason | EXCLUDED: Editor's note of concern due to concerns raised regarding the authenticity of the data presented within the article |
Abu Hashim Acta Obstet Gynecol Scand 2012; 91:338-45 10.1111/j.1600-0412.2011.01346.x |
| Johnson, 1990 | other reason | EXCLUDED: Article retracted in Pubmed. | |
| Lipitz, 1993 | other reason | EXCLUDED: Study in triplet pregnancies, which is difficult to extrapolate to the population of pregnant women. |
Lipitz Fertil Steril 1993; 60:1031-4 10.1016/s0015-0282(16)56405-x |
| Ardalan, 2012 | not about fetal exposure | EXCLUDED: Exposure period not sufficiently defined to ensure exposure during pregnancy (given the half-life) | |
| Werler, 1994 | not about fetal exposure | EXCLUDED: Exposure period not sufficiently defined (or > 3 months) to ensure exposure during pregnancy (given the half-life). | |
| Whiteman, 2000 | not about fetal exposure | EXCLUDED: Exposure period not sufficiently defined to ensure exposure during pregnancy (given the half-life). |
Whiteman Am J Epidemiol 2000; 152:823-8 10.1093/aje/152.9.823 |
| Sharma, 2014 | not about fetal exposure | EXCLUDED: Exposure period not sufficiently defined to ensure exposure during pregnancy (given the half-life). |
Sharma PLoS One 2014; 9:e108219 10.1371/journal.pone.0108219 |
| Mills, 1990 | not about fetal exposure | EXCLUDED: Exposure period not sufficiently defined to ensure exposure during pregnancy (given the half-life). Among controls: 16.8% had reported subfertility. Material and Methods completed with Mills 1989. Results completed with Mills 1991. | |
| Kurachi, 1983 | not about fetal exposure | EXCLUDED: Exposure period not sufficiently defined to ensure exposure during pregnancy (given the half-life). |
Kurachi Fertil Steril 1983; 40:187-9 10.1016/s0015-0282(16)47235-3 |
| Ross, 2003 | not about fetal exposure | EXCLUDED: Exposure period not sufficiently defined to ensure exposure during pregnancy (given the half-life). |
Ross Cancer Causes Control 2003; 14:447-51 10.1023/a:1024953532355 |
| Ott, 2010 | not about fetal exposure | EXCLUDED: Exposure period not sufficiently defined to ensure exposure during pregnancy (given the half-life). |
Ott Reprod Biol Endocrinol 2010; 8:45 10.1186/1477-7827-8-45 |
| Bhattacharya, 2008 | not about fetal exposure | EXCLUDED: Exposure period not sufficiently defined to ensure exposure during pregnancy (given the half-life) | |
| Zhou, 2022 | not about fetal exposure | EXCLUDED: Exposure period not sufficiently defined to ensure exposure during pregnancy (given the half-life). |
Zhou J Obstet Gynaecol 2022; 42:316-321 10.1080/01443615.2021.1904224 |
| Cuckle, 1989 | not about fetal exposure | EXCLUDED: Exposure period not sufficiently defined to ensure exposure during pregnancy (given the half-life). | |
| Brinton, 2004 | not relevant study design | EXCLUDED: Comparison to expected rates: not adequate study design ('Expected rates available for the time period 1943–1996 from the Danish Cancer Registry'). |
Brinton Fertil Steril 2004; 81:1083-91 10.1016/j.fertnstert.2003.08.042 |
| Auyeung, 2001 | data not abstractable | EXCLUDED: No births in the non-exposed control group (i.e natural cycle–IUI). The other group was treated with injectable gonadotropins–IUI, whose safety in pregnancy is not well established => inadequate control group. |
Auyeung J Assist Reprod Genet 2001; 18:638-43 10.1023/a:1013159116180 |
| Turner, 2006 | data not abstractable | EXCLUDED: The number of live-births not provided by group of treatment and there is on-going pregnancies => Denominators cannot be determined based on provided data. |
Turner J Obstet Gynaecol 2006; 26:233-5 10.1080/01443610600555295 |
| Forman, 2007 | same data already obtained by other studies | Overlapping: Foreman 2007 includes data from 2 of the 5 centers included in the Tulandi 2006 study. => Use of Tulandi 2006 which includes more women exposed. |
Forman J Obstet Gynaecol Can 2007; 29:668-71 10.1016/s1701-2163(16)32551-8 |
| Check, 1987 | article unavailable | EXCLUDED: Publication not found despite deep search and probably no distinction between patients treated with hMG or clomiphene citrate according to the abstract. | |
| Sanam, 2008 | article unavailable | EXCLUDED: Publication not found despite deep search and probably no distinction between patients treated with clomiphene citrate alone or with human menopausal gonadotropin according to the abstract. | |
| Balen, 1994 | article unavailable | EXCLUDED: Publication not found despite deep search and probably a study on the efficacy of clomiphene, including the miscarriage outcome, studied as an efficacy criteria rather than a safety one. | |
| Huaqing, 2023 | article unavailable | EXCLUDED: Publication not found despite deep search. |
Huaqing, S. Chinese J. Reprod. Contracep. 2023; 43:989-. 10.3760/cma.j.cn101441-20220826-00355 |
| Sarkar, 2022 | Studies without separate analysis of the considered drug/class from other drugs/class | EXCLUDED: Analysis of pregnancy outcomes in women with minimal and mild endometriosis versus unexplained infertility, without distinction between treatments. |
Sarkar J Hum Reprod Sci 2022; 15:272-277 10.4103/jhrs.jhrs_102_22 |
| Zadehmodarres, 2009 | Studies without separate analysis of the considered drug/class from other drugs/class | EXCLUDED: Analysis of clomiphene citrate and/or gonadotropins as a whole, without distinction of women treated with clomifene. |
Zadehmodarres J Assist Reprod Genet 2009; 26:7-11 10.1007/s10815-008-9273-7 |
| Van Steensel-Moll, 1985 | Studies without separate analysis of the considered drug/class from other drugs/class | EXCLUDED: Analysis of female hormones, but no specific analysis of clomiphene (raw data of exposure provided for the cases but not for the controls). |
van Steensel-Moll Int J Epidemiol 1985; 14:555-9 10.1093/ije/14.4.555 |
| Frederick, 1994 | Studies without separate analysis of the considered drug/class from other drugs/class | EXCLUDED: Pregnancy outcomes provided without distinction of the ovarian stimulation protocol used (with or without clomiphene). |
Frederick Hum Reprod 1994; 9:2284-6 10.1093/oxfordjournals.humrep.a138438 |
| Matsuzaki, 2017 | Studies without separate analysis of the considered drug/class from other drugs/class | EXCLUDED: Study on the efficacy of metformin, with or without clomiphene. Miscarriage outcome, studied as an efficacy criteria rather than a safety one. Malformations and complications during pregnancy reported but co-exposure with clomiphene unknown. |
Matsuzaki Reprod Med Biol 2017; 16:179-187 10.1002/rmb2.12026 |
| Siristatidis b, 2017 | Studies without separate analysis of the considered drug/class from other drugs/class | EXCLUDED: Analysis of women exposed to Clomiphene citrate or Letrozole as a whole, without distinction between treatments. Study on the efficacy of clomiphene, including miscarriage outcome, studied as an efficacy criteria rather than a safety one. |
Siristatidis Gynecol Endocrinol 2017; 33:553-556 10.1080/09513590.2017.1296128 |
| Carson, 2013 | Studies without separate analysis of the considered drug/class from other drugs/class | EXCLUDED: No details on the exposure in the group that conceived after ovulation-inducing drugs => there is clomiphene ('such as clomiphene citrate') but other drugs are also possible. |
Carson Fertil Steril 2013; 99:456-63 10.1016/j.fertnstert.2012.10.029 |
| Sheikhi, 2018 | efficacy rather than safety aims | EXCLUDED: Randomized control trial studying the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one. |
Sheikhi JBRA Assist Reprod 2018; 22:221-227 10.5935/1518-0557.20180040 |
| Xu, 2014 | efficacy rather than safety aims | EXCLUDED: Randomized control trial studying the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one. |
Xu, B.-F. J. Reprod. Contracept. 2014; 25:41-. 10.7669/j.issn.1001-7844.2014.01.0041 |
| Bateman, 1992 | efficacy rather than safety aims | EXCLUDED: Study assessing the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one. | |
| Homburg, 2006 | efficacy rather than safety aims | EXCLUDED: Study assessing the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one. |
Homburg Gynecol Endocrinol 2006; 22:506-10 10.1080/09513590600921366 |
| Costello, 1998 | efficacy rather than safety aims | EXCLUDED: Study assessing the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one. | |
| Ghazeeri, 2003 | efficacy rather than safety aims | EXCLUDED: Randomized control trial studying the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one. |
Ghazeeri Fertil Steril 2003; 79:562-6 10.1016/s0015-0282(02)04843-4 |
| Dickey, 1996 | efficacy rather than safety aims | EXCLUDED: Study assessing the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one. |
Dickey Hum Reprod 1996; 11:2623-8 10.1093/oxfordjournals.humrep.a019182 |
| Hernandez-Nieto, 2023 | efficacy rather than safety aims | EXCLUDED: Study assessing the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one. |
Hernandez-Nieto Hum Reprod 2023; 38:1151-1161 10.1093/humrep/dead072 |
| Hakim, 1995 | efficacy rather than safety aims | EXCLUDED: Study assessing the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one. |
Hakim Am J Obstet Gynecol 1995; 172:1510-7 10.1016/0002-9378(95)90489-1 |
| Mitwally, 2005 | efficacy rather than safety aims | EXCLUDED: Study assessing the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one. |
Mitwally Am J Obstet Gynecol 2005; 192:381-6 10.1016/j.ajog.2004.08.013 |
| Gradel, 2023 | efficacy rather than safety aims | EXCLUDED: Study assessing the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one. |
Gradel Arch Gynecol Obstet 2023; 307:1073-1081 10.1007/s00404-022-06878-6 |
| Luo, 2023 | efficacy rather than safety aims | EXCLUDED: Study assessing the efficacy of clomiphene, including the miscarriage outcome that is studied as an efficacy criteria rather than a safety one. |
Luo Eur J Obstet Gynecol Reprod Biol 2023; 286:61-68 10.1016/j.ejogrb.2023.05.005 |
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