Proton Pump Inhibitors

Study	Exclusion reasons	Rmk	Reference
Wilton (Pantoprazole), 2003	inadequate or absent control group	EXCLUDED : because there isn't a control population for pregnant women.	Wilton Drug Saf 2003; 26:121-32 10.2165/00002018-200326020-00005
Wilton (Lansoprazole), 1998	inadequate or absent control group	EXCLUDED: the study don't have a proper control group. It's all the other women already exposed to other treatment studied.	Wilton Br J Obstet Gynaecol 1998; 105:882-9 10.1111/j.1471-0528.1998.tb10234.x
Wilton, 1998	inadequate or absent control group	EXCLUDED: the study don't have a proper control group. It's all the other women already exposed to other treatment studied.	Wilton Br J Obstet Gynaecol 1998; 105:882-9 10.1111/j.1471-0528.1998.tb10234.x
Wilton (Omeprazole), 1998	inadequate or absent control group	EXCLUDED: the study don't have a proper control group. It's all the other women already exposed to other treatment studied.	Wilton Br J Obstet Gynaecol 1998; 105:882-9 10.1111/j.1471-0528.1998.tb10234.x
Lee a, 2022	data not abstractable	EXCLUDED: data provided by authors (logistic regression coefficients for each type of preterm birth without confidence interval and average values of random forest variable importance) not abstractable.	Lee Int J Environ Res Public Health 2022; 19: 10.3390/ijerph19053056
Lee b, 2022	data not abstractable	EXCLUDED: data provided by authors (logistic regression coefficients for each type of preterm birth without confidence interval and average values of random forest variable importance) not abstractable.	Lee Arch Gynecol Obstet 2022; 305:1369-1376 10.1007/s00404-022-06405-7
Acs (Omeprazole), 2009	repeat population groups, duplicate reports (most recent study included)	EXCLUDED: This study is included in the publication of Bànhidy et al. 2011 (same database, study period, outcome but less exposed and non-exposed in the result).	Acs Acta Obstet Gynecol Scand 2009; 88:1017-23 10.1080/00016340903128447
Cluver, 2015	repeat population groups, duplicate reports (most recent study included)	EXCLUDED: because this study is included in the publication of Cluver et al. 2018.	Cluver BMJ Open 2015; 5:e008211 10.1136/bmjopen-2015-008211
Lalkin (Omeprazole), 1997	repeat population groups, duplicate reports (most recent study included)	EXCLUDED : because the study is included in the publication of Lalkin et al. 1998.	Lalkin Can Fam Physician 1997; 43:1923-4, 1927
Erichsen, 2014	same data already obtained by other studies	EXCLUDED: Hypospadias are already assessed in the publication of Pasternak et al. 2010 (same database and study period but with more exposed pregnancies).	Erichsen Am J Ther ; 2014; 21:254-9
Einarson, 2002	no specific data	EXCLUDED: general review of the most frequently ask questions about drug exposure during pregnancy and breastfeeding. No specific outcomes were shared.	Einarson Can Fam Physician 2002; 48:1301-4
Robinson, 2019	Studies without separate analysis of the considered drug/class from other drugs/class	EXCLUDED: because it present an analysis of antacids as a whole without distinction of PPIs.	Robinson J Allergy Clin Immunol Pract ; 7:2422-2424.e4 10.1016/j.jaip.2019.02.039
Mulder, 2013	Studies without separate analysis of the considered drug/class from other drugs/class	EXCLUDED: study without a separate analysis of the considered class from another class. And the same database is used in the publication of Mulder et al. 2014 with a wider study period.	Mulder J. Allergy Clin. Immunol. 2013; 132:1438-40 10.1016/j.jaci.2013.07.012
Chen, 2010	Studies without separate analysis of the considered drug/class from other drugs/class	EXCLUDED: studies without separate analysis of the considered IPPs from H2RA.	Chen Am. J. Obstet. Gynecol. 2010; 202:164.e1-8 10.1016/j.ajog.2009.09.029
Michel, 2023	Studies without separate analysis of the considered drug/class from other drugs/class	EXCLUDED: OR based on dichotomized variable only provided for maternal QT-prolonging drugs as a whole without distinction between treatments. Results for PPIs, SSRIs, and dimenhydrinate only, only provided as a continuous variable (mean postnatal QTc).	Michel Front. Pharmacol. 2023; 14:247-. 10.3389/fphar.2023.1193317