Teriflunomide

Study	Exclusion reasons	Rmk	Reference
Vukusic, 2019	inadequate or absent control group		Vukusic Mult. Scler. 2019; :1352458519843055 10.1177/1352458519843055
O'Connor, 2011	case report or case series	11 pregnancies occurred: 4 spontaneous abortions (1 in the placebo group and 3 in TERI group), 6 induced abortions (5 in the lower-dose TERI group and 1 in the higher-dose TERI group), 1 healthy baby (higher-dose TERI group).	O'Connor N. Engl. J. Med. 2011; 365:1293-303 10.1056/NEJMoa1014656
Andersen (men patients), 2018	other reason		Andersen JB Front Immunol 2018;9:2706 10.3389/fimmu.2018.02706
Andersen (women patients), 2018	not in pregnancy		Andersen JB Front Immunol 2018;9:2706 10.3389/fimmu.2018.02706
Leray E, 2018	repeat population groups, duplicate reports (most recent study included)		Leray E European committee for treatment and research in multiple sclerosis 2018;229093
Oger, 2017	repeat population groups, duplicate reports (most recent study included)		Oger Final scientific report 2017:1-66