Thiouracil, propylthiouracil, benzylthiouracil


Study Exclusion reasons Rmk Reference
Burrow (PTU only), 1978 not relevant outcome EXCLUDED: IQ provided as continuous variable or as deviation of normal values (but only on figures). Nb of goiter and/or hypo or hyperthyroidism were reporter for PTU exposed neonates but not for unexposed group.

Burrow The Yale journal of biology and medicine. 1978;51:151-156.

Andersen 2013 (control unexposed, disease free), 2013 repeat population groups, duplicate reports (most recent study included) EXCLUDED: Andersen 2019 published an update analysis of this study Andersen 2013 based on a longer period and including more participants.

Andersen J. Clin. Endocrinol. Metab. 2013; 98:4373-81 10.1210/jc.2013-2831

Andersen 2013 (control unexposed, sick), 2013 repeat population groups, duplicate reports (most recent study included) EXCLUDED: Andersen 2019 published an update analysis of this study Andersen 2013 based on a longer period and including more participants.

Andersen J. Clin. Endocrinol. Metab. 2013; 98:4373-81 10.1210/jc.2013-2831

Andersen 2013 (control exposed to MMI/CMZ), 2013 repeat population groups, duplicate reports (most recent study included) EXCLUDED: Andersen 2019 published an update analysis of this study Andersen 2013 based on a longer period and including more participants.

Andersen J. Clin. Endocrinol. Metab. 2013; 98:4373-81 10.1210/jc.2013-2831

Andersen 2014 (control exposed to MMI), 2014 repeat population groups, duplicate reports (most recent study included) EXCLUDED: Andersen 2019 published an update analysis of this study Andersen 2014 based on a longer period and including more participants.

Andersen Thyroid 2014; 24:1533-40 10.1089/thy.2014.0150

Andersen 2014 (control unexposed, disease free), 2014 repeat population groups, duplicate reports (most recent study included) EXCLUDED: Andersen 2019 published an update analysis of this study Andersen 2014 based on a longer period and including more participants.

Andersen Thyroid 2014; 24:1533-40 10.1089/thy.2014.0150

Andersen 2014 (control unexposed, sick), 2014 repeat population groups, duplicate reports (most recent study included) EXCLUDED: Andersen 2019 published an update analysis of this study Andersen 2014 based on a longer period and including more participants.

Andersen Thyroid 2014; 24:1533-40 10.1089/thy.2014.0150

Momotani, 1977 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: no distinction between MMI and PTU exposure.

Momotani Nihon Naibunpi Gakkai Zasshi 1977; 53:1148-58 10.1507/endocrine1927.53.10_1148