Phenytoin (All indications)

Study	Exclusion reasons	Rmk	Reference
Vajda (Phenytoin) (Controls exposed to Lamotrigine, sick), 2018		Overlapping between Vajda 2024a (1999 - 2023) and Vajda 2018 (1999 - 2016) based on the same register and for the almost same outcome (with or without elective termination) => Use of Vajda 2024a because accounting for more relevant confounders.	Vajda Acta Neurol Scand 2018; 137:20-23 10.1111/ane.12816
Vajda (Phenytoin) (Controls unexposed, sick), 2018		Overlapping between Vajda 2024a (1999 - 2023) and Vajda 2018 (1999 - 2016) based on the same register and for the almost same outcome (with or without elective termination) => Use of Vajda 2024a because accounting for more relevant confounders.	Vajda Acta Neurol Scand 2018; 137:20-23 10.1111/ane.12816
Gopinath (Phenytoin), 2015	repeat population groups, duplicate reports (most recent study included)	Overlapping: Thomas 2022 included data on language and cognitive delay, also evaluated in Sreedharan et al., 2018; Thomas 2007 and Gopinath 2015, but with more exposed pregnancies, more relevant control group and older children => Use of Thomas 2022.	Gopinath Epilepsy Res 2015; 117:58-62 10.1016/j.eplepsyres.2015.09.003
Thomas (Phenytoin), 2007	repeat population groups, duplicate reports (most recent study included)	Overlapping: Thomas 2022 included data on language and cognitive delay, also evaluated in Sreedharan et al., 2018; Thomas 2007 and Gopinath 2015, but with more exposed pregnancies, more relevant control group and older children => Use of Thomas 2022.	Thomas Epilepsia 2007; 48:2234-40 10.1111/j.1528-1167.2007.01376.x