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Rabeprazole
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Pasternak, 2010 Choi a, 2023
2
1.11
[
0.72
; 1.73]
108,275
13,456
not evaluable
Major congenital malformations
Pasternak, 2010 Choi a, 2023
2
1.11
[
0.72
; 1.73]
108,275
13,456
not evaluable
Cleft palate
Choi a, 2023
1
1.22
[
0.72
; 2.07]
2,296
13,414
not evaluable
Congenital heart defects
Choi a, 2023
1
1.05
[
0.93
; 1.19]
42,419
13,414
not evaluable
Hydrocephaly
Choi a, 2023
1
1.57
[
0.75
; 3.30]
791
13,414
not evaluable
Hypospadias
Choi a, 2023
1
0.83
[
0.42
; 1.63]
1,808
6,899
not evaluable
Growth parameters and prematurity
Low birth weight (< 2500g)
Choi b, 2023
1
1.00
[
0.92
; 1.08]
104,732
11,934
not evaluable
0.2
5.0
1.0
