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Flunitrazepam
Overall results
Study description
Excluded studies
Table
Graphic
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during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Källén, 2013 Noh, 2022
2
1.33
[
1.05
; 1.69]
206,471
1,008
not evaluable
Congenital heart defects
Källén, 2013 Noh, 2022
2
1.64
[
1.20
; 2.24]
83,627
1,008
not evaluable
Major congenital malformations
Källén, 2013 Noh, 2022
2
1.33
[
1.05
; 1.69]
206,471
1,008
not evaluable
Growth parameters and prematurity
Preterm (< 37 weeks)
Meng a (Controls unexposed, sick), 2023
1
1.62
[
1.44
; 1.83]
275,110
2,581
not evaluable
Small for gestational age (weight)
Meng a (Controls unexposed, sick), 2023
1
1.60
[
1.42
; 1.81]
288,359
2,612
not evaluable
Intrauterine deaths
Late intrauterine deaths (> 22 weeks) / Stillbirths
Meng a (Controls unexposed, sick), 2023
1
0.92
[
0.62
; 1.37]
34,543
2,612
not evaluable
0.5
5.0
1.0