Aripiprazole

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations All congenital malformations (majors, minors, majors and minors, or unspecified) Habermann (Control unexposed, disease free), 2013 Bellet, 2015 Raguideau, 2017 Freeman, 2021 Huybrechts (Controls unexposed, sick), 2023 51.40[0.91; 2.17]30,5664,929serious Major congenital malformations Habermann (Control unexposed, disease free), 2013 Bellet, 2015 Raguideau, 2017 Freeman, 2021 Huybrechts (Controls unexposed, sick), 2023 51.36[0.88; 2.11]30,5574,929not evaluable Ano-rectal atresia and stenosis Raguideau, 2017 Huybrechts (Controls unexposed, sick), 2023 20.72[0.14; 3.54]5744,651not evaluable Gastroschisis Raguideau, 2017 Huybrechts (Controls unexposed, sick), 2023 21.82[0.10; 34.19]2474,651not evaluable Oesophageal atresia with or without tracheo-oesophageal fistula Raguideau, 2017 Huybrechts (Controls unexposed, sick), 2023 21.37[0.28; 6.75]4184,651not evaluable Congenital heart defects Huybrechts (Controls unexposed, sick), 2023 11.10[0.84; 1.45]-3,861not evaluable Digestive system anomalies Ellfolk (Controls unexposed NOS), 2021 11.96[0.04; 95.27]46220not evaluable Hip dislocation and/or dysplasia Huybrechts (Controls unexposed, sick), 2023 10.64[0.21; 1.97]-3,861not evaluable Hydrocephaly Huybrechts (Controls unexposed, sick), 2023 10.64[0.16; 2.57]-3,861not evaluable Limb defects Ellfolk (Controls unexposed NOS), 2021 11.21[0.19; 7.74]237220not evaluable Limb reduction defects (LRD) Huybrechts (Controls unexposed, sick), 2023 12.04[0.51; 8.15]-3,861not evaluable Nervous system anomalies Ellfolk (Controls unexposed NOS), 2021 11.08[0.07; 17.55]47220not evaluable Oro-facial clefts Huybrechts (Controls unexposed, sick), 2023 10.66[0.27; 1.60]-3,861not evaluable Respiratory system anomalies Ellfolk (Controls unexposed NOS), 2021 12.50[0.15; 41.51]20220not evaluable Atrial septal defect Raguideau, 2017 11.40[0.28; 6.93]3,584790not evaluable Bilateral renal agenesis including Potter syndrome Raguideau, 2017 115.84[0.98; 255.77]75790not evaluable Bladder exstrophy and/or epispadia Raguideau, 2017 114.49[0.90; 233.88]82790not evaluable Cleft lip with or without cleft palate Raguideau, 2017 1----- Cleft palate Raguideau, 2017 12.00[0.19; 21.07]1,222790not evaluable Club foot / Talipes equinovarus Raguideau, 2017 12.90[0.49; 17.07]1,696790not evaluable Coarctation of aorta Raguideau, 2017 11.45[0.09; 23.19]825790not evaluable Craniosynostosis Raguideau, 2017 13.10[0.24; 40.89]779790not evaluable Diaphragmatic hernia Raguideau, 2017 13.03[0.19; 48.58]394790not evaluable Ebstein's anomaly Raguideau, 2017 122.78[1.40; 369.30]52790not evaluable Hypoplastic left heart (HLH/HLHS) Raguideau, 2017 15.03[0.31; 80.79]237790not evaluable Hypoplastic right heart (HRH/HRHS) Raguideau, 2017 116.49[1.02; 266.45]72790not evaluable Hypospadias Raguideau, 2017 11.40[0.28; 7.07]3,406790not evaluable Microcephaly / Small head circumference for gestational age Raguideau, 2017 12.52[0.16; 40.38]474790not evaluable Multicystic renal dysplasia Raguideau, 2017 11.72[0.11; 27.61]693790not evaluable Omphalocele Raguideau, 2017 14.22[0.26; 67.65]283790not evaluable Polydactyly Raguideau, 2017 13.08[0.19; 49.33]388790not evaluable Pulmonary artery atresia Raguideau, 2017 17.45[0.46; 119.73]160790not evaluable Spina bifida Raguideau, 2017 13.80[0.26; 55.72]625790not evaluable Tetralogy of Fallot Raguideau, 2017 11.85[0.12; 29.71]644790not evaluable Transposition of the great vessels Raguideau, 2017 12.18[0.14; 34.92]548790not evaluable Ventricular septal defect Raguideau, 2017 11.90[0.60; 6.01]5,013790not evaluable Growth parameters and prematurity Preterm (< 37 weeks) Bellet, 2015 12.57[1.06; 6.25]2267not evaluable Small for gestational age (weight) Bellet, 2015 12.97[1.23; 7.17]2363not evaluable Maternal consequences Gestational diabetes Bellet, 2015 Park, 2018 Wang - UK cohort, 2021 31.24[0.53; 2.92]130505not evaluable Preeclampsia Bellet, 2015 10.66[0.07; 6.35]486not evaluable Neonatal disorders Neonatal disorders (as a whole) Habermann (Control unexposed, disease free), 2013 16.95[2.17; 22.20]4717not evaluable Intrauterine deaths Early intrauterine deaths (< 22 weeks) / Spontaneous abortions Paulus, 2013 Bellet, 2015 Sorensen, 2015 Ishikawa, 2024 41.47[0.82; 2.63]158,485593not evaluable Elective/induced termination of pregnancy Paulus, 2013 Bellet, 2015 26.65[2.83; 15.61]27154not evaluable Therapeutic terminations of pregnancy Bellet, 2015 16.05[0.24; 151.25]186not evaluable Neuro-developmental disorders Cognitive developmental disorders/delay (> 6 years old) Straub, 2022 Bruno, 2024 21.53[0.86; 2.73]4,199523not evaluable Language disorders/delay Straub, 2022 Bruno, 2024 21.36[0.77; 2.43]78,5212,201not evaluable Learning disorders Straub, 2022 Bruno, 2024 20.69[0.29; 1.66]6,775463not evaluable Neuro-developmental disorders (as a whole) Straub, 2022 Bruno, 2024 21.33[1.12; 1.58]160,3272,261not evaluable Severe cognitive developmental delay (Mental retardation) (> 6 years old) Straub, 2022 Bruno, 2024 21.53[0.86; 2.73]4,199523not evaluable ADHD (Attention deficit hyperactivity disorder): Diagnosis Straub, 2022 11.36[0.98; 1.89]62,4081,738not evaluable ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk Straub, 2022 11.36[0.98; 1.89]62,4081,738not evaluable ASD (Autism spectrum disorder): Diagnosis Straub, 2022 11.49[0.90; 2.45]13,4481,738not evaluable ASD (Autism spectrum disorder): Diagnosis/Risk Straub, 2022 11.49[0.90; 2.45]13,4481,738not evaluable Psychomotor developmental disorders/delay Straub, 2022 11.05[0.55; 2.01]11,8771,738not evaluable0.0100.01.0

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