Olanzapine

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations All congenital malformations (majors, minors, majors and minors, or unspecified) McKenna, 2005 Peng, 2013 Källen, 2013 Raguideau, 2017 Huybrechts (Controls unexposed, sick), 2023 Viguera, 2023 Chan (Controls unexposed, sick), 2024 71.17[0.98; 1.39]30,8583,534not evaluable Major congenital malformations McKenna, 2005 Peng, 2013 Källen, 2013 Raguideau, 2017 Huybrechts (Controls unexposed, sick), 2023 Viguera, 2023 Chan (Controls unexposed, sick), 2024 71.17[0.98; 1.39]30,8583,534not evaluable Congenital heart defects Huybrechts (Controls unexposed, sick), 2023 Chan (Controls unexposed, sick), 2024 21.09[0.78; 1.52]1372,442not evaluable Ano-rectal atresia and stenosis Raguideau, 2017 Huybrechts (Controls unexposed, sick), 2023 22.44[0.85; 6.96]5743,111not evaluable Microcephaly / Small head circumference for gestational age Boden (Control unexposed, NOS), 2012 Raguideau, 2017 20.77[0.26; 2.28]474956not evaluable Digestive system anomalies Ellfolk (Controls unexposed NOS), 2021 14.33[0.63; 29.68]47413not evaluable Hip dislocation and/or dysplasia Huybrechts (Controls unexposed, sick), 2023 10.36[0.05; 2.57]-2,341not evaluable Hydrocephaly Huybrechts (Controls unexposed, sick), 2023 10.30[0.04; 2.19]-2,341not evaluable Limb defects Ellfolk (Controls unexposed NOS), 2021 13.71[1.36; 10.15]242413not evaluable Limb reduction defects (LRD) Huybrechts (Controls unexposed, sick), 2023 12.26[0.32; 16.00]-2,341not evaluable Nervous system anomalies Ellfolk (Controls unexposed NOS), 2021 11.00[0.08; 12.55]49413not evaluable Oro-facial clefts Huybrechts (Controls unexposed, sick), 2023 12.56[1.22; 5.38]-2,341not evaluable Respiratory system anomalies Ellfolk (Controls unexposed NOS), 2021 11.43[0.04; 48.60]21413not evaluable Atrial septal defect Raguideau, 2017 11.40[0.28; 7.00]3,584770not evaluable Bilateral renal agenesis including Potter syndrome Raguideau, 2017 116.25[1.01; 262.42]75770not evaluable Bladder exstrophy and/or epispadia Raguideau, 2017 114.87[0.92; 239.97]82770not evaluable Cleft lip with or without cleft palate Raguideau, 2017 12.90[0.56; 15.00]1,677770not evaluable Cleft palate Raguideau, 2017 11.00[0.06; 16.07]1,221770not evaluable Club foot / Talipes equinovarus Raguideau, 2017 12.90[0.56; 14.93]1,696770not evaluable Coarctation of aorta Raguideau, 2017 11.49[0.09; 23.79]825770not evaluable Craniosynostosis Raguideau, 2017 11.58[0.10; 25.23]778770not evaluable Diaphragmatic hernia Raguideau, 2017 13.11[0.19; 49.84]394770not evaluable Ebstein's anomaly Raguideau, 2017 123.37[1.44; 378.91]52770not evaluable Gastroschisis Raguideau, 2017 14.98[0.31; 79.86]246770not evaluable Hypoplastic left heart (HLH/HLHS) Raguideau, 2017 15.17[0.32; 82.90]237770not evaluable Hypoplastic right heart (HRH/HRHS) Raguideau, 2017 116.92[1.05; 273.39]72770not evaluable Hypospadias Raguideau, 2017 1----- Multicystic renal dysplasia Raguideau, 2017 11.77[0.11; 28.33]693770not evaluable Oesophageal atresia with or without tracheo-oesophageal fistula Raguideau, 2017 12.93[0.18; 46.98]418770not evaluable Omphalocele Raguideau, 2017 14.33[0.27; 69.41]283770not evaluable Polydactyly Raguideau, 2017 13.16[0.20; 50.62]388770not evaluable Pulmonary artery atresia Raguideau, 2017 17.64[0.48; 122.84]160770not evaluable Spina bifida Raguideau, 2017 13.90[0.26; 57.98]625770not evaluable Tetralogy of Fallot Raguideau, 2017 11.90[0.12; 30.48]644770not evaluable Transposition of the great vessels Raguideau, 2017 12.24[0.14; 35.83]548770not evaluable Ventricular septal defect Raguideau, 2017 11.00[0.17; 6.00]5,011770not evaluable Growth parameters and prematurity Preterm (< 37 weeks) Newport, 2007 Boden (Control unexposed, NOS), 2012 Vigod, 2015 Ozturk, 2016 41.28[0.77; 2.11]184354not evaluable Small for gestational age (weight) Boden (Control unexposed, NOS), 2012 Vigod, 2015 21.71[1.07; 2.72]65353not evaluable Large for gestational age (length) Boden (Control unexposed, NOS), 2012 11.94[0.87; 4.33]-186not evaluable Large for gestational age (weight) Boden (Control unexposed, NOS), 2012 10.55[0.14; 2.14]-187not evaluable Large head circumference for gestational age Boden (Control unexposed, NOS), 2012 13.02[1.60; 5.71]2186not evaluable Small for gestational age (length) Boden (Control unexposed, NOS), 2012 11.17[0.54; 2.54]-186not evaluable Low birth weight (< 2500g) Newport, 2007 111.84[0.57; 247.85]414not evaluable Macrosomia (> 4000g) Newport, 2007 10.92[0.05; 16.46]214not evaluable Maternal consequences Gestational diabetes Boden (Control unexposed, NOS), 2012 Vigod, 2015 Park, 2018 Wang - HK cohort, 2021 Wang - UK cohort, 2021 51.53[1.17; 2.00]6,209719not evaluable Preeclampsia Vigod, 2015 11.03[0.45; 2.32]49166not evaluable Neonatal disorders Neonatal disorders (as a whole) Habermann (Unexposed control), 2013 14.02[2.07; 7.81]5686not evaluable Infant health status Wurtz, 2017 11.01[0.91; 1.12]--not evaluable Neonatal death (< 28 days of life) Källen, 2013 11.19[0.77; 1.84]-101not evaluable Neonatal medical care Newport, 2007 111.84[0.57; 247.85]414not evaluable Intrauterine deaths Early intrauterine deaths (< 22 weeks) / Spontaneous abortions Sorensen, 2015 Ozturk, 2016 Ishikawa, 2024 31.00[0.80; 1.25]158,486403not evaluable Elective/induced termination of pregnancy Ozturk, 2016 12.00[0.10; 38.88]145not evaluable Neuro-developmental disorders Cognitive developmental disorders/delay (> 6 years old) Straub, 2022 Bruno, 2024 20.80[0.35; 1.85]4,2152,727not evaluable Language disorders/delay Straub, 2022 Bruno, 2024 20.92[0.73; 1.16]78,5242,676not evaluable Learning disorders Straub, 2022 Bruno, 2024 20.70[0.38; 1.29]6,7901,181not evaluable Neuro-developmental disorders (as a whole) Straub, 2022 Bruno, 2024 20.93[0.80; 1.09]160,3702,895not evaluable Severe cognitive developmental delay (Mental retardation) (> 6 years old) Straub, 2022 Bruno, 2024 20.80[0.35; 1.85]4,2152,727not evaluable ADHD (Attention deficit hyperactivity disorder): Diagnosis Straub, 2022 10.98[0.78; 1.24]62,4551,495not evaluable ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk Straub, 2022 10.98[0.78; 1.24]62,4551,495not evaluable ASD (Autism spectrum disorder): Diagnosis Straub, 2022 11.00[0.60; 1.68]9,6171,327not evaluable ASD (Autism spectrum disorder): Diagnosis/Risk Straub, 2022 11.00[0.60; 1.68]9,6171,327not evaluable Psychomotor developmental disorders/delay Straub, 2022 10.89[0.40; 2.00]8,2211,327not evaluable0.0100.01.0

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