Risperidone Paliperidone

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations All congenital malformations (majors, minors, majors and minors, or unspecified) Reis (Unexposed control, NOS), 2008 Shechtman (Unexposed control), 2009 Peng, 2013 Raguideau, 2017 Huybrechts (Controls unexposed, sick), 2023 Chan (Controls unexposed, sick), 2024 61.34[1.13; 1.59]61,5302,999not evaluable Major congenital malformations Reis (Unexposed control, NOS), 2008 Shechtman (Unexposed control), 2009 Peng, 2013 Raguideau, 2017 Huybrechts (Controls unexposed, sick), 2023 Chan (Controls unexposed, sick), 2024 61.34[1.13; 1.59]61,5302,999not evaluable Congenital heart defects Huybrechts (Controls unexposed, sick), 2023 Chan (Controls unexposed, sick), 2024 20.99[0.67; 1.47]1362,319not evaluable Ano-rectal atresia and stenosis Raguideau, 2017 Huybrechts (Controls unexposed, sick), 2023 21.82[0.52; 6.29]5742,777not evaluable Gastroschisis Raguideau, 2017 Huybrechts (Controls unexposed, sick), 2023 22.32[0.67; 8.04]2462,777not evaluable Digestive system anomalies Ellfolk (Controls unexposed NOS), 2021 11.19[0.08; 17.85]46242not evaluable Hip dislocation and/or dysplasia Huybrechts (Controls unexposed, sick), 2023 11.21[0.39; 3.75]-2,270not evaluable Hydrocephaly Huybrechts (Controls unexposed, sick), 2023 12.16[0.81; 5.75]-2,270not evaluable Limb defects Ellfolk (Controls unexposed NOS), 2021 12.77[0.92; 8.32]238242not evaluable Limb reduction defects (LRD) Huybrechts (Controls unexposed, sick), 2023 14.01[1.00; 16.06]-2,270not evaluable Nervous system anomalies Ellfolk (Controls unexposed NOS), 2021 11.00[0.06; 16.18]48242not evaluable Neural Tube Defects Huybrechts (Controls unexposed, sick), 2023 11.86[0.26; 13.26]-2,270not evaluable Oro-facial clefts Huybrechts (Controls unexposed, sick), 2023 10.85[0.27; 2.65]-2,270not evaluable Respiratory system anomalies Ellfolk (Controls unexposed NOS), 2021 12.27[0.14; 37.71]20242not evaluable Atrial septal defect Raguideau, 2017 15.50[2.43; 12.45]3,588507not evaluable Bilateral renal agenesis including Potter syndrome Raguideau, 2017 124.69[1.53; 398.87]75507not evaluable Bladder exstrophy and/or epispadia Raguideau, 2017 122.59[1.40; 364.74]82507not evaluable Cleft lip with or without cleft palate Raguideau, 2017 11.11[0.07; 17.80]1,675507not evaluable Cleft palate Raguideau, 2017 13.10[0.24; 40.77]1,222507not evaluable Club foot / Talipes equinovarus Raguideau, 2017 14.40[0.77; 25.05]1,696507not evaluable Coarctation of aorta Raguideau, 2017 12.26[0.14; 36.16]825507not evaluable Craniosynostosis Raguideau, 2017 12.39[0.15; 38.35]778507not evaluable Diaphragmatic hernia Raguideau, 2017 14.72[0.29; 75.76]394507not evaluable Ebstein's anomaly Raguideau, 2017 135.50[2.19; 575.92]52507not evaluable Hypoplastic left heart (HLH/HLHS) Raguideau, 2017 17.85[0.49; 126.00]237507not evaluable Hypoplastic right heart (HRH/HRHS) Raguideau, 2017 125.71[1.59; 415.53]72507not evaluable Hypospadias Raguideau, 2017 12.20[0.43; 11.29]3,406507not evaluable Microcephaly / Small head circumference for gestational age Raguideau, 2017 17.80[0.53; 115.56]475507not evaluable Multicystic renal dysplasia Raguideau, 2017 12.69[0.17; 43.06]693507not evaluable Oesophageal atresia with or without tracheo-oesophageal fistula Raguideau, 2017 14.45[0.28; 71.41]418507not evaluable Omphalocele Raguideau, 2017 16.57[0.41; 105.50]283507not evaluable Polydactyly Raguideau, 2017 14.80[0.30; 76.93]388507not evaluable Pulmonary artery atresia Raguideau, 2017 111.61[0.72; 186.72]160507not evaluable Spina bifida Raguideau, 2017 12.98[0.19; 47.82]624507not evaluable Tetralogy of Fallot Raguideau, 2017 12.89[0.18; 46.34]644507not evaluable Transposition of the great vessels Raguideau, 2017 13.40[0.21; 54.46]548507not evaluable Ventricular septal defect Raguideau, 2017 1----- Growth parameters and prematurity Preterm (< 37 weeks) Newport, 2007 Vigod, 2015 Ozturk, 2016 31.02[0.57; 1.83]169120not evaluable Low birth weight (< 2500g) Newport, 2007 18.33[0.28; 244.06]16not evaluable Macrosomia (> 4000g) Newport, 2007 10.70[0.02; 20.03]16not evaluable Maternal consequences Gestational diabetes Vigod, 2015 Park, 2018 Wang - HK cohort, 2021 31.03[0.70; 1.51]183471not evaluable Preeclampsia Vigod, 2015 11.55[0.68; 3.55]49112not evaluable Neonatal disorders Neonatal medical care Newport, 2007 12.27[0.04; 129.96]-6not evaluable Withdrawal syndrome / Neonatal abstinence syndrome / Poor neonatal adaptation Shechtman (Control exposed to Haloperidol), 2009 11.68[0.48; 5.90]1271not evaluable Intrauterine deaths Early intrauterine deaths (< 22 weeks) / Spontaneous abortions Yaris, 2005 Sorensen, 2015 Ozturk, 2016 Ishikawa, 2024 41.31[0.72; 2.38]158,481232not evaluable Elective/induced termination of pregnancy Shechtman (Unexposed control), 2009 Ozturk, 2016 24.57[1.41; 14.77]24108not evaluable Neuro-developmental disorders Cognitive developmental disorders/delay (> 6 years old) Straub, 2022 Bruno, 2024 21.45[0.71; 3.00]4,1991,603not evaluable Language disorders/delay Straub, 2022 Bruno, 2024 20.87[0.66; 1.15]58,2021,603not evaluable Learning disorders Straub, 2022 Bruno, 2024 20.88[0.27; 2.91]6,775294not evaluable Neuro-developmental disorders (as a whole) Straub, 2022 Bruno, 2024 20.95[0.69; 1.31]160,3321,698not evaluable Severe cognitive developmental delay (Mental retardation) (> 6 years old) Straub, 2022 Bruno, 2024 21.45[0.71; 3.00]4,1991,603not evaluable ADHD (Attention deficit hyperactivity disorder): Diagnosis Straub, 2022 11.01[0.78; 1.30]62,4371,404not evaluable ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk Straub, 2022 11.01[0.78; 1.30]62,4371,404not evaluable ASD (Autism spectrum disorder): Diagnosis Straub, 2022 10.62[0.31; 1.24]9,5911,309not evaluable ASD (Autism spectrum disorder): Diagnosis/Risk Straub, 2022 10.62[0.31; 1.24]9,5911,309not evaluable Psychomotor developmental disorders/delay Straub, 2022 11.44[0.77; 2.69]8,2411,309not evaluable0.0100.01.0

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