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Overall results
Study description
Excluded studies
Table
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during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
Major congenital malformations
Shapira, 2020
1
1.21
[
0.24
; 6.16]
6
88
not evaluable
Growth parameters and prematurity
Small for gestational age (weight)
Shapira, 2020
1
0.55
[
0.21
; 1.45]
19
107
not evaluable
Intrauterine deaths
Early intrauterine death (< 22 weeks)
Shapira, 2020
1
0.08
[
0.00
; 1.41]
6
100
not evaluable
Intrauterine deaths (as a whole or unspecified)
Shapira, 2020
1
0.17
[
0.02
; 1.39]
7
108
not evaluable
Neuro-developmental disorders
Neuro-developmental disorders (as a whole)
Fejzo, 2015
1
1.26
[
0.08
; 20.37]
138
2
not evaluable
0.0
50.0
1.0