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Infliximab
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Hyrich, 2006 Weber-Schoendorfer, 2015 De Lorenzo (Controls unexposed, sick), 2020
3
3.30
[
1.43
; 7.61]
28
161
not evaluable
Major congenital malformations
Hyrich, 2006 Weber-Schoendorfer, 2015
2
3.11
[
1.32
; 7.31]
28
158
not evaluable
Growth parameters and prematurity
Preterm (< 37 weeks)
De Lorenzo (Controls unexposed, sick), 2020
1
1.63
[
0.06
; 41.29]
3
3
not evaluable
Small for gestational age (weight)
De Lorenzo (Controls unexposed, sick), 2020
1
7.50
[
0.46
; 122.70]
3
3
not evaluable
Macrosomia (> 4000g)
De Lorenzo (Controls unexposed, sick), 2020
1
12.60
[
0.20
; 780.42]
-
3
not evaluable
Maternal consequences
Caesarean
0
-
-
-
-
-
Neonatal disorders
Neonatal infections
Vinet (Unexposed controls, sick), 2018
1
4.37
[
1.30
; 14.71]
52
37
not evaluable
Neonatal disorders (as a whole)
0
-
-
-
-
-
Neonatal medical care
0
-
-
-
-
-
Intrauterine deaths
Elective/induced termination of pregnancy
Hyrich, 2006
1
3.40
[
0.05
; 219.14]
-
3
not evaluable
Early intrauterine death (< 22 weeks)
Hyrich, 2006
1
4.00
[
0.17
; 95.76]
2
3
not evaluable
Intrauterine deaths (as a whole or unspecified)
0
-
-
-
-
-
Late intrauterine deaths (> 22 weeks)
0
-
-
-
-
-
Therapeutic terminations of pregnancy
0
-
-
-
-
-
0.0
100.0
1.0