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Fingolimod
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
Major congenital malformations
Karlsson (control unexposed, sick), 2014 Pauliat, 2020
2
0.85
[
0.06
; 12.12]
6
74
not evaluable
All congenital malformations (majors, minors, majors and minors, or unspecified)
Karlsson (control unexposed, sick), 2014
1
0.12
[
0.00
; 7.22]
3
32
not evaluable
Growth parameters and prematurity
Preterm (< 37 weeks)
Nguyen (control unexposed, sick), 2019 Pauliat, 2020
2
1.32
[
0.47
; 3.69]
192
50
not evaluable
Intrauterine deaths
Elective/induced termination of pregnancy
Karlsson (control unexposed, sick), 2014 Nguyen (control unexposed, sick), 2019 Pauliat, 2020
3
0.88
[
0.16
; 4.97]
82
136
not evaluable
Early intrauterine death (< 22 weeks)
Karlsson (control unexposed, sick), 2014 Pauliat, 2020
2
0.77
[
0.30
; 2.00]
28
124
not evaluable
Intrauterine deaths (as a whole or unspecified)
Nguyen (control unexposed, sick), 2019
1
1.30
[
0.16
; 10.24]
51
12
not evaluable
Therapeutic terminations of pregnancy
Pauliat, 2020
1
0.98
[
0.06
; 16.09]
2
63
not evaluable
0.0
20.0
1.0