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Interferon beta 1a (IFN-beta1a)
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Weber-Schoendorfer (control unexposed, sick), 2009
1
0.55
[
0.10
; 2.97]
7
40
not evaluable
Major congenital malformations
Weber-Schoendorfer (control unexposed, sick), 2009
1
0.19
[
0.01
; 3.85]
3
40
not evaluable
Congenital cataract
0
-
-
-
-
-
Growth parameters and prematurity
Preterm (< 37 weeks)
Weber-Schoendorfer (control unexposed, sick), 2009 Fragoso a (control unexposed, sick), 2013 Nguyen (control unexposed, sick), 2019
3
1.16
[
0.45
; 2.99]
249
292
not evaluable
Maternal consequences
Preeclampsia
Fragoso a (control unexposed, sick), 2013
1
1.10
[
0.11
; 10.95]
4
29
not evaluable
Gestational diabetes
Fragoso a (control exposed to Glatiramer), 2013
1
0.44
[
0.02
; 11.17]
1
29
not evaluable
Neonatal disorders
Jaundice / Icterus
Fragoso a (control unexposed, sick), 2013
1
0.81
[
0.16
; 4.02]
10
29
not evaluable
Long term consequences
Child/Infant infections (> 1 year)
Fragoso a (control unexposed, sick), 2013
1
3.75
[
1.00
; 14.02]
10
29
not evaluable
Child/Infant weight abnormalities (> 1 year)
Fragoso a (control unexposed, sick), 2013
1
3.36
[
0.20
; 55.42]
2
29
not evaluable
Intrauterine deaths
Intrauterine deaths (as a whole or unspecified)
Weber-Schoendorfer (control unexposed, sick), 2009 Nguyen (control unexposed, sick), 2019
2
0.73
[
0.41
; 1.31]
71
292
not evaluable
Elective/induced termination of pregnancy
Nguyen (control unexposed, sick), 2019
1
1.62
[
0.83
; 3.13]
41
250
not evaluable
Neuro-developmental disorders
Psychomotor developmental disorders/delay
Fragoso a (control unexposed, sick), 2013
1
10.31
[
0.41
; 260.28]
1
29
not evaluable
ASD (Autism spectrum disorder): Diagnosis
Fragoso a (control unexposed, sick), 2013
1
10.31
[
0.41
; 260.28]
1
29
not evaluable
ASD (Autism spectrum disorder): Diagnosis/Risk
Fragoso a (control unexposed, sick), 2013
1
10.31
[
0.41
; 260.28]
1
29
not evaluable
ADHD (Attention deficit hyperactivity disorder): Diagnosis
Fragoso a (control unexposed, sick), 2013
1
0.65
[
0.03
; 13.92]
2
29
not evaluable
ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk
Fragoso a (control unexposed, sick), 2013
1
0.65
[
0.03
; 13.92]
2
29
not evaluable
Cognitive developmental disorders/delay (> 6 years old)
Fragoso a (control unexposed, sick), 2013
1
1.66
[
0.15
; 19.00]
3
29
not evaluable
Language disorders/delay
Fragoso a (control exposed to Glatiramer), 2013
1
0.44
[
0.02
; 11.17]
1
29
not evaluable
Learning disorders
Fragoso a (control unexposed, sick), 2013
1
1.09
[
0.04
; 27.59]
1
29
not evaluable
0.0
100.0
1.0