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Tacrolimus (all routes)
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Wielgos, 2012 Perales-Puchalt, 2012
2
0.46
[
0.07
; 3.05]
4
30
not evaluable
Major congenital malformations
Wielgos, 2012
1
0.37
[
0.04
; 3.14]
4
21
not evaluable
Growth parameters and prematurity
Preterm (< 37 weeks)
Perales-Puchalt, 2012 Kim, 2015 Ichinose, 2018 Al-Otaibi, 2019
4
0.99
[
0.36
; 2.69]
50
82
not evaluable
Low birth weight (< 2500g)
Kim, 2015 Ichinose, 2018
2
2.02
[
0.86
; 4.75]
27
43
not evaluable
Small for gestational age (weight)
Thompson, 2003 Perales-Puchalt, 2012
2
0.87
[
0.12
; 6.18]
12
13
not evaluable
Maternal consequences
Preeclampsia
Thompson, 2003 Perales-Puchalt, 2012 Wielgos, 2012 Alvaro, 2013
4
2.26
[
0.63
; 8.11]
19
49
not evaluable
Caesarean
Perales-Puchalt, 2012 Kim, 2015 Al-Otaibi, 2019
3
1.34
[
0.73
; 2.48]
92
70
not evaluable
Gestational diabetes
Wielgos, 2012
1
1.31
[
0.05
; 35.47]
1
21
not evaluable
Maternal consequences (as a whole)
Sugawara, 2019
1
1.18
[
0.36
; 3.87]
34
16
not evaluable
Neonatal disorders
Fetal distress
Ichinose, 2018
1
0.48
[
0.04
; 5.18]
-
15
not evaluable
Intrauterine deaths
Early intrauterine death (< 22 weeks)
Al-Otaibi, 2019
1
7.95
[
0.37
; 171.28]
2
33
not evaluable
Late intrauterine deaths (> 22 weeks)
Perales-Puchalt, 2012 Al-Otaibi, 2019
2
0.95
[
0.04
; 20.57]
3
42
not evaluable
0.0
100.0
1.0
