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Nortriptyline
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Paternal exp. genotoxic window only (0–3 months preconception)
Paternal exposure: epigenetic window only (3–xxx months preconception)
Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception)
Paternal exposure: other window
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Anderson, 2020
1
1.00
[
0.27
; 3.77]
30,630
11
not evaluable
Major congenital malformations
Anderson, 2020
1
1.00
[
0.27
; 3.77]
30,630
11
not evaluable
Growth parameters and prematurity
Large for gestational age (weight)
Lee (Controls unexposed, general pop), 2025
1
0.62
[
0.15
; 2.54]
9,746
117
not evaluable
Low birth weight (< 2500g)
Lee (Controls unexposed, general pop), 2025
1
1.53
[
0.92
; 2.54]
31,365
117
not evaluable
Preterm (< 37 weeks)
Lee (Controls unexposed, general pop), 2025
1
0.94
[
0.50
; 1.75]
28,554
117
not evaluable
Small for gestational age (weight)
Lee (Controls unexposed, general pop), 2025
1
0.72
[
0.18
; 2.90]
6,988
117
not evaluable
Maternal consequences
Assisted deliveries (forceps, vacuum, ...)
Lee (Controls unexposed, general pop), 2025
1
1.26
[
0.71
; 2.24]
46,049
117
not evaluable
Caesarean
Lee (Controls unexposed, general pop), 2025
1
1.03
[
0.70
; 1.52]
111,678
117
not evaluable
Maternal consequences (as a whole)
Lee (Controls unexposed, general pop), 2025
1
1.09
[
0.71
; 1.67]
311,181
117
not evaluable
Postpartum hemorrhage
Lee (Controls unexposed, general pop), 2025
1
0.96
[
0.42
; 2.19]
19,761
117
not evaluable
Neonatal disorders
Low Apgar score (< 7) (at 1 min)
Lee (Controls unexposed, general pop), 2025
1
1.53
[
0.71
; 3.30]
14,890
117
not evaluable
Low Apgar score (< 7) (at 5 min)
Lee (Controls unexposed, general pop), 2025
1
1.15
[
0.07
; 18.52]
1,721
117
not evaluable
Neonatal death (< 28 days of life)
Lee (Controls unexposed, general pop), 2025
1
3.17
[
0.20
; 50.97]
627
117
not evaluable
Neonatal disorders (as a whole)
Lee (Controls unexposed, general pop), 2025
1
1.52
[
1.05
; 2.19]
161,467
117
not evaluable
Neonatal medical care
Lee (Controls unexposed, general pop), 2025
1
1.46
[
0.59
; 3.60]
8,571
117
not evaluable
Long term consequences
Child/Infant death (> 28 days of life)
Lee (Controls unexposed, general pop), 2025
1
15.24
[
0.94
; 246.37]
130
117
not evaluable
Intrauterine deaths
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions
Kjaersgaard (Controls unexposed, sick), 2013
1
0.87
[
0.42
; 1.80]
-
-
not evaluable
0.0
100.0
1.0
