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Overall results
Study description
Excluded studies
Table
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during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Paternal exp. genotoxic window only (0–3 months preconception)
Paternal exposure: epigenetic window only (3–xxx months preconception)
Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception)
Paternal exposure: other window
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Einarson, 2009 Ozturk, 2016 Anderson, 2020 Chan (Controls unexposed, pop general), 2024
4
2.39
[
0.74
; 7.73]
53,288
73
not evaluable
Major congenital malformations
Einarson, 2009 Ozturk, 2016 Anderson, 2020 Chan (Controls unexposed, pop general), 2024
4
2.39
[
0.74
; 7.73]
53,288
73
not evaluable
Congenital heart defects
Chan (Controls unexposed, pop general), 2024
1
0.81
[
0.05
; 13.25]
8,107
35
not evaluable
Cleft lip with or without cleft palate
0
-
-
-
-
-
Cleft palate
0
-
-
-
-
-
Oro-facial clefts
0
-
-
-
-
-
Growth parameters and prematurity
Preterm (< 37 weeks)
Ozturk, 2016
1
27.94
[
0.52
; 1494.23]
8
1
not evaluable
Maternal consequences
Preeclampsia
Palmsten a (Controls unexposed, sick), 2013
1
0.63
[
0.38
; 1.05]
3,229
339
not evaluable
Postpartum hemorrhage
Palmsten b, 2013
1
1.85
[
0.90
; 3.80]
1,887
139
not evaluable
Neonatal disorders
Neonatal medical care
Khazaie (Controls unexposed, sick), 2013
1
1.00
[
0.02
; 53.28]
-
18
not evaluable
Intrauterine deaths
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions
Yaris, 2005 Ozturk, 2016
2
19.92
[
1.21
; 328.36]
24
2
not evaluable
Elective/induced termination of pregnancy
Ozturk, 2016
1
17.97
[
0.34
; 938.20]
14
1
not evaluable
0.0
100.0
1.0