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Desvenlafaxine
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Paternal exp. genotoxic window only (0–3 months preconception)
Paternal exposure: epigenetic window only (3–xxx months preconception)
Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception)
Paternal exposure: other window
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Anderson, 2020
1
0.75
[
0.14
; 4.09]
30,630
6
not evaluable
Congenital heart defects
0
-
-
-
-
-
Major congenital malformations
Anderson, 2020
1
0.75
[
0.14
; 4.09]
30,630
6
not evaluable
Growth parameters and prematurity
Preterm (< 37 weeks)
Marks, 2021
1
0.81
[
0.18
; 3.64]
63
16
not evaluable
Neonatal disorders
Jaundice / Icterus
Marks, 2021
1
1.26
[
0.35
; 4.54]
66
16
not evaluable
Low Apgar score (< 7) (at 5 min)
Marks, 2021
1
1.64
[
0.45
; 5.97]
53
16
not evaluable
Neonatal medical care
Marks, 2021
1
0.98
[
0.26
; 3.72]
94
16
not evaluable
Neonatal tachypnea
Marks, 2021
1
0.34
[
0.02
; 5.75]
35
16
not evaluable
Persistent pulmonary hypertension
Marks, 2021
1
26.16
[
0.50
; 1362.35]
-
16
not evaluable
Withdrawal syndrome / Neonatal abstinence syndrome / Poor neonatal adaptation
Marks, 2021
1
1.13
[
0.13
; 9.68]
20
16
not evaluable
0.0
100.0
1.0
