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Diltiazem (versus unexposed)
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Weber-Schoendorfer, 2008
1
0.75
[
0.10
; 5.67]
34
29
not evaluable
Limb defects
Weber-Schoendorfer, 2008
1
3.61
[
0.18
; 71.49]
3
29
not evaluable
Major congenital malformations
Weber-Schoendorfer, 2008
1
0.86
[
0.05
; 14.73]
14
29
not evaluable
Growth parameters and prematurity
Preterm (< 37 weeks)
Weber-Schoendorfer, 2008
1
3.75
[
1.45
; 9.65]
53
29
not evaluable
Intrauterine deaths
Early intrauterine death (< 22 weeks)
Weber-Schoendorfer, 2008
1
2.43
[
0.97
; 6.07]
65
36
not evaluable
Elective/induced termination of pregnancy
Weber-Schoendorfer, 2008
1
4.43
[
1.73
; 11.35]
36
41
not evaluable
Late intrauterine deaths (> 22 weeks)
Weber-Schoendorfer, 2008
1
1.72
[
0.09
; 31.08]
6
35
not evaluable
0.0
100.0
1.0
