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Midazolam
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Noh, 2022
1
1.26
[
1.17
; 1.35]
157,637
8,609
not evaluable
Congenital heart defects
Noh, 2022
1
1.34
[
1.22
; 1.47]
84,054
8,609
not evaluable
Major congenital malformations
Noh, 2022
1
1.26
[
1.17
; 1.35]
157,637
8,609
not evaluable
Growth parameters and prematurity
Preterm (< 37 weeks)
Meng a (Controls unexposed, sick), 2023
1
1.35
[
1.14
; 1.60]
266,124
1,269
not evaluable
Small for gestational age (weight)
Meng a (Controls unexposed, sick), 2023
1
1.32
[
1.12
; 1.56]
273,301
1,318
not evaluable
Intrauterine deaths
Late intrauterine deaths (> 22 weeks) / Stillbirths
Meng a (Controls unexposed, sick), 2023
1
2.70
[
1.99
; 3.67]
36,541
1,317
not evaluable
0.8
5.0
1.0