Etanercept

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations All congenital malformations (majors, minors, majors and minors, or unspecified) Hyrich, 2006 Chambers, 2015 Weber-Schoendorfer, 2015 Hoxha, 2017 Fu, 2019 De Lorenzo (Controls unexposed, sick), 2020 Drechsel, 2020 72.93[1.53; 5.60]34238not evaluable Major congenital malformations Hyrich, 2006 Chambers, 2015 Weber-Schoendorfer, 2015 Hoxha, 2017 Fu, 2019 Drechsel, 2020 62.61[1.40; 4.86]31232not evaluable Congenital heart defects 0----- Digestive system anomalies 0----- Ear malformations 0----- Eye defects 0----- Limb defects 0----- Nervous system anomalies 0----- Oro-facial clefts 0----- Respiratory system anomalies 0----- Growth parameters and prematurity Preterm (< 37 weeks) Chambers, 2015 Hoxha, 2017 Carman (Control unexposed, sick), 2017 De Lorenzo (Controls unexposed, sick), 2020 Drechsel, 2020 51.50[1.10; 2.04]323249not evaluable Small for gestational age (weight) De Lorenzo (Controls unexposed, sick), 2020 Drechsel, 2020 24.36[0.71; 26.61]615not evaluable Low birth weight (< 2500g) Carman (Control unexposed, sick), 2017 11.71[1.14; 2.58]203217not evaluable Macrosomia (> 4000g) De Lorenzo (Controls unexposed, sick), 2020 15.73[0.10; 320.07]-6not evaluable Maternal consequences Caesarean 0----- Preeclampsia Fu, 2019 Drechsel, 2020 20.67[0.02; 19.22]11104not evaluable Gestational diabetes Drechsel, 2020 11.25[0.13; 11.76]79not evaluable Maternal consequences (as a whole) Hoxha, 2017 13.62[0.16; 83.53]217not evaluable Neonatal disorders Neonatal infections Vinet (Unexposed controls, sick), 2018 Drechsel, 2020 21.82[0.83; 3.97]58204not evaluable Low Apgar score (< 7) (at 5 min) 0----- Neonatal death (< 28 days of life) Drechsel, 2020 17.71[0.14; 414.30]-9not evaluable Intrauterine deaths Early intrauterine death (< 22 weeks) Hyrich, 2006 Chambers, 2015 Carman (Control unexposed, sick), 2017 Fu, 2019 Drechsel, 2020 50.66[0.30; 1.45]622832not evaluable Elective/induced termination of pregnancy Hyrich, 2006 Carman (Control unexposed, sick), 2017 Drechsel, 2020 31.03[0.70; 1.52]293367not evaluable Late intrauterine deaths (> 22 weeks) Carman (Control unexposed, sick), 2017 Drechsel, 2020 20.82[0.22; 3.09]28350not evaluable Ectopic pregnancy Drechsel, 2020 122.04[0.85; 573.89]113not evaluable Intrauterine deaths (as a whole or unspecified) Hoxha, 2017 10.36[0.05; 2.59]517not evaluable0.0100.01.0

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