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Interferon beta 1b (IFN-beta1b)
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Weber-Schoendorfer (control unexposed, sick), 2009 Colvin, 2010
2
1.71
[
0.37
; 7.96]
5,001
21
not evaluable
Major congenital malformations
Weber-Schoendorfer (control unexposed, sick), 2009 Colvin, 2010
2
1.88
[
0.33
; 10.69]
4,998
21
not evaluable
Growth parameters and prematurity
Preterm (< 37 weeks)
Weber-Schoendorfer (control unexposed, sick), 2009 Fragoso a (control unexposed, sick), 2013 Nguyen (control unexposed, sick), 2019
3
1.32
[
0.31
; 5.56]
206
68
not evaluable
Maternal consequences
Preeclampsia
Fragoso a (control unexposed, sick), 2013
1
7.58
[
1.10
; 52.23]
5
10
not evaluable
Gestational diabetes
Fragoso a (control exposed to Glatiramer), 2013
1
1.32
[
0.05
; 34.93]
1
10
not evaluable
Neonatal disorders
Jaundice / Icterus
Fragoso a (control unexposed, sick), 2013
1
1.21
[
0.14
; 10.79]
9
10
not evaluable
Neonatal medical care
Fragoso a (control unexposed, sick), 2013
1
10.44
[
0.60
; 181.46]
2
10
not evaluable
Long term consequences
Child/Infant infections (> 1 year)
Fragoso a (control unexposed, sick), 2013
1
2.00
[
0.21
; 19.05]
6
10
not evaluable
Child/Infant weight abnormalities (> 1 year)
Fragoso a (control unexposed, sick), 2013
1
3.28
[
0.12
; 86.28]
1
10
not evaluable
Intrauterine deaths
Intrauterine deaths (as a whole or unspecified)
Weber-Schoendorfer (control unexposed, sick), 2009 Nguyen (control unexposed, sick), 2019
2
1.70
[
0.43
; 6.67]
64
70
not evaluable
Elective/induced termination of pregnancy
Nguyen (control unexposed, sick), 2019
1
2.27
[
0.76
; 6.76]
31
52
not evaluable
Neuro-developmental disorders
ADHD (Attention deficit hyperactivity disorder): Diagnosis
Fragoso a (control unexposed, sick), 2013
1
1.95
[
0.09
; 43.62]
2
10
not evaluable
ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk
Fragoso a (control unexposed, sick), 2013
1
1.95
[
0.09
; 43.62]
2
10
not evaluable
Cognitive developmental disorders/delay (> 6 years old)
Fragoso a (control unexposed, sick), 2013
1
1.95
[
0.09
; 43.62]
2
10
not evaluable
Language disorders/delay
Fragoso a (control exposed to Glatiramer), 2013
1
1.32
[
0.05
; 34.93]
1
10
not evaluable
Learning disorders
Fragoso a (control unexposed, sick), 2013
1
3.28
[
0.12
; 86.28]
1
10
not evaluable
Psychomotor developmental disorders/delay
Fragoso a (control exposed to Glatiramer), 2013
1
1.32
[
0.05
; 34.93]
1
10
not evaluable
0.0
100.0
1.0
