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Esomeprazole
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Pasternak, 2010 Choi a, 2023
2
1.10
[
1.02
; 1.19]
108,332
13,184
not evaluable
Major congenital malformations
Pasternak, 2010 Choi a, 2023
2
1.10
[
1.02
; 1.19]
108,332
13,184
not evaluable
Cleft palate
Choi a, 2023
1
0.97
[
0.53
; 1.78]
2,292
12,516
not evaluable
Congenital heart defects
Choi a, 2023
1
1.09
[
0.97
; 1.23]
42,434
12,516
not evaluable
Hydrocephaly
Choi a, 2023
1
0.43
[
0.11
; 1.71]
786
12,516
not evaluable
Hypospadias
Choi a, 2023
1
0.64
[
0.30
; 1.37]
1,806
6,476
not evaluable
Growth parameters and prematurity
Extremely preterm (< 28 weeks)
Cluver, 2018
1
1.13
[
0.64
; 1.99]
-
59
not evaluable
Low birth weight (< 2500g)
Choi b, 2023
1
0.93
[
0.86
; 1.01]
104,782
12,868
not evaluable
Preterm (< 37 weeks)
Cluver, 2018
1
1.07
[
0.68
; 1.68]
-
59
not evaluable
Small for gestational age (weight)
Cluver, 2018
1
1.81
[
0.87
; 3.77]
68
59
not evaluable
Maternal consequences
Abruptio placentae (retroplacental hematoma)
Cluver, 2018
1
0.07
[
0.00
; 1.28]
6
59
not evaluable
Maternal consequences (as a whole)
Cluver, 2018
1
0.24
[
0.03
; 2.23]
5
59
not evaluable
Postpartum hemorrhage
Cluver, 2018
1
0.14
[
0.01
; 2.73]
3
59
not evaluable
Preeclampsia
Cluver, 2018
1
0.14
[
0.01
; 2.73]
3
59
not evaluable
Neonatal disorders
Fetal distress
Cluver, 2018
1
1.18
[
0.57
; 2.43]
54
59
not evaluable
Low Apgar score (< 7) (at 5 min)
Cluver, 2018
1
0.13
[
0.02
; 1.10]
8
59
not evaluable
Necrotizing enterocolitis
Cluver, 2018
1
1.38
[
0.30
; 6.46]
7
59
not evaluable
Neonatal death (< 28 days of life)
Cluver, 2018
1
0.76
[
0.26
; 2.20]
16
59
not evaluable
Neonatal disorders (as a whole)
Cluver, 2018
1
0.91
[
0.35
; 2.34]
21
59
not evaluable
Neonatal infections
Cluver, 2018
1
1.98
[
0.62
; 6.31]
14
59
not evaluable
Neonatal intracranial hemorrhage
Cluver, 2018
1
5.27
[
0.25
; 112.09]
2
59
not evaluable
Neonatal medical care
Cluver, 2018
1
2.20
[
0.62
; 7.73]
12
59
not evaluable
Intrauterine deaths
Late intrauterine deaths (> 22 weeks)
Cluver, 2018
1
1.02
[
0.06
; 16.65]
2
59
not evaluable
0.0
100.0
1.0
