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Lacosamide (All indications)
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
The Kerala Registry for Epilepsy and Pregnancy (Epilepsy) (Controls unexposed, sick), 2024 The Australian Pregnancy Register of Antiepileptic Drugs (Mixed indications) (Controls unexposed, sick), 2024 The NAAED (Controls unexposed, disease free) (Indications NOS), 2024 Battino (Epilepsy), 2024 The UKIEPR (Epilepsy) (Controls unexposed, sick), 2024
5
1.55
[
0.41
; 5.79]
161
137
serious
Major congenital malformations
The Kerala Registry for Epilepsy and Pregnancy (Epilepsy) (Controls unexposed, sick), 2024 The Australian Pregnancy Register of Antiepileptic Drugs (Mixed indications) (Controls unexposed, sick), 2024 The NAAED (Controls unexposed, disease free) (Indications NOS), 2024 Battino (Epilepsy), 2024 The UKIEPR (Epilepsy) (Controls unexposed, sick), 2024
5
1.55
[
0.41
; 5.79]
161
137
serious
0.2
10.0
1.0
