Vigabatrin (All indications)

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations All congenital malformations (majors, minors, majors and minors, or unspecified) Morrow (Vigabatrin) (Controls unexposed, sick), 2006 Mawer (Vigabatrin) (Controls unexposed, sick), 2010 Källén (Vigabatrin) (Controls unexposed, NOS) (Indications NOS), 2013 Vajda (Vigabatrin) (Controls unexposed, sick), 2019 Battino (Vigabatrin) (Epilepsy), 2024 56.04[1.59; 23.00]49,62421not evaluable Major congenital malformations Morrow (Vigabatrin) (Controls unexposed, sick), 2006 Mawer (Vigabatrin) (Controls unexposed, sick), 2010 Källén (Vigabatrin) (Controls unexposed, NOS) (Indications NOS), 2013 Vajda (Vigabatrin) (Controls unexposed, sick), 2019 Battino (Vigabatrin) (Epilepsy), 2024 56.04[1.59; 23.00]49,62421not evaluable Microcephaly / Small head circumference for gestational age Christensen (Vigabatrin) (Epilepsy) (Controls unexposed, general population), 2024 11.81[0.10; 31.40]6999not evaluable Congenital heart defects Morrow (Vigabatrin) (Controls exposed to Lamotrigine, sick), 2006 112.98[0.62; 271.33]46not evaluable Digestive system anomalies Morrow (Vigabatrin) (Controls exposed to Lamotrigine, sick), 2006 116.71[0.77; 363.61]36not evaluable Hypospadias Morrow (Vigabatrin) (Controls exposed to Lamotrigine, sick), 2006 18.96[0.45; 179.29]66not evaluable Limb defects Morrow (Vigabatrin) (Controls exposed to Lamotrigine, sick), 2006 123.44[1.00; 547.07]26not evaluable Neural Tube Defects Morrow (Vigabatrin) (Controls exposed to Lamotrigine, sick), 2006 139.12[1.43; 1070.14]16not evaluable Oro-facial clefts Morrow (Vigabatrin) (Controls exposed to Lamotrigine, sick), 2006 139.12[1.43; 1070.14]16not evaluable Growth parameters and prematurity Preterm (< 37 weeks) Kilic (Vigabatrin) (Controls unexposed, sick) (Mixed indications), 2014 10.51[0.03; 8.67]38313not evaluable Low birth weight (< 2500g) Christensen (Vigabatrin) (Epilepsy) (Controls unexposed, general population), 2024 11.24[0.07; 21.50]1,0069not evaluable Small for gestational age (weight) Christensen (Vigabatrin) (Epilepsy) (Controls unexposed, general population), 2024 10.48[0.03; 8.36]2,4169not evaluable0.0100.01.0

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