Labetalol (versus unexposed)

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations Atrial septal defect Fisher, 2017 Bergman, 2018 22.01[1.20; 3.37]7,02283not evaluable Congenital heart defects Fisher, 2017 Bergman, 2018 21.34[0.72; 2.46]43,092123not evaluable Hypospadias Van Zutphen, 2014 Bergman, 2018 21.47[0.35; 6.14]10,28721not evaluable All congenital malformations (majors, minors, majors and minors, or unspecified) Delteil, 2024 11.66[0.93; 2.96]4,066289not evaluable Cleft lip with or without cleft palate Bergman, 2018 10.70[0.19; 2.62]3,62346not evaluable Cleft palate Bergman, 2018 10.50[0.08; 3.16]1,99945not evaluable Club foot / Talipes equinovarus Bergman, 2018 10.80[0.27; 2.40]4,413-not evaluable Coarctation of aorta Fisher, 2017 14.31[1.66; 11.17]-23not evaluable Congenital hydronephrosis Bergman, 2018 10.70[0.21; 2.37]4,993-not evaluable Ebstein's anomaly Caton, 2009 114.63[0.70; 307.82]653not evaluable Hip dislocation and/or dysplasia Bergman, 2018 10.90[0.29; 2.75]4,670-not evaluable Major congenital malformations Delteil, 2024 11.66[0.93; 2.96]4,066289not evaluable Multicystic renal dysplasia Bergman, 2018 13.80[1.31; 11.05]1,334-not evaluable Neural Tube Defects Bergman, 2018 10.90[0.19; 4.27]3,89046not evaluable Pulmonary valve stenosis Fisher, 2017 12.58[1.00; 6.66]--not evaluable Ventricular septal defect Fisher, 2017 15.26[0.70; 39.41]--not evaluable Growth parameters and prematurity Small for gestational age (weight) Cruickshank, 1990 Petersen, 2012 Thewissen (Controls unexposed, sick), 2017 Duan, 2018 Xiang, 2020 Fitton (Controls unexposed, sick), 2020 Delteil, 2024 71.86[1.29; 2.68]142,1075,904not evaluable Preterm (< 37 weeks) Cruickshank, 1991 Petersen, 2012 Xiang, 2020 31.33[0.50; 3.51]109,7321,627not evaluable Low birth weight (< 2500g) Duan, 2018 15.92[5.46; 6.41]20,2133,357not evaluable Very low birth weight (< 1500g) Duan, 2018 18.60[7.52; 9.83]3,6893,357not evaluable Maternal consequences Caesarean Cruickshank, 1991 Duan, 2018 Xiang, 2020 31.27[0.43; 3.76]106,1243,535not evaluable Preeclampsia Duan, 2018 Xiang, 2020 21.30[0.17; 9.84]2,5033,484not evaluable Abruptio placentae (retroplacental hematoma) Xiang, 2020 10.27[0.13; 0.59]40127not evaluable Assisted deliveries (forceps, vacuum, ...) Duan, 2018 10.67[0.51; 0.89]8,2833,357not evaluable Maternal death Xiang, 2020 10.99[0.02; 50.39]-127not evaluable Neonatal disorders Neonatal medical care Thewissen (Controls unexposed, sick), 2017 Xiang, 2020 22.05[1.18; 3.53]84146not evaluable Jaundice / Icterus Chan, 2010 Xiang, 2020 22.85[1.60; 5.08]68156not evaluable Low Apgar score (< 7) (at 5 min) Sibai, 1990 Duan, 2018 22.29[0.87; 5.98]3,1153,443not evaluable Neonatal hypoglycemia Bateman, 2016 Xiang, 2020 21.78[1.55; 2.04]9466,854not evaluable Neonatal intracranial hemorrhage Thewissen (Controls unexposed, sick), 2017 11.00[0.13; 7.81]422not evaluable Fetal distress Chan, 2010 13.14[1.01; 9.74]1732not evaluable Low Apgar score (< 7) (at 1 min) Duan, 2018 12.71[2.43; 3.02]17,1333,357not evaluable Low Apgar score (< 7) (at 10 min) Duan, 2018 12.43[1.70; 3.48]1,4613,357not evaluable Neonatal bradycardia Bateman, 2016 11.34[1.08; 1.67]3996,730not evaluable Neonatal death (< 28 days of life) Xiang, 2020 11.68[0.59; 4.78]16124not evaluable Neonatal disorders (as a whole) Chan, 2010 14.25[1.51; 11.98]2432not evaluable Neonatal hypotension Xiang, 2020 18.02[2.32; 27.66]24124not evaluable Very low Apgar score (< 5) (at 1 min) Sibai, 1990 11.20[0.44; 3.26]1786not evaluable Intrauterine deaths Intrauterine deaths (as a whole or unspecified) Xiang, 2020 10.59[0.14; 2.50]8127not evaluable Perinatal death Petersen, 2012 12.08[1.26; 3.44]6,0781,452not evaluable Neuro-developmental disorders Cognitive developmental disorders/delay (3-6 years old) Chan, 2010 11.50[0.65; 3.47]-32not evaluable Language disorders/delay Chan, 2010 10.85[0.37; 1.96]-32not evaluable0.0100.01.0

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